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Updated: Jan 29, 2026

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在ATP结合性ACC1-13K8中,拥挤诱导的液体-液体相分离导致了明显的氨基酸变体

Robert Dec1, Wojciech Dzwolak2, Roland Winter1

  • 1Physical Chemistry I - Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn Street 4a, 44227 Dortmund, Germany.

Biomacromolecules
|January 27, 2026
PubMed
概括

像聚乙烯糖醇 (PEG) 一样,宏分子拥挤可以诱导中的液体液相分离 (LLPS),促进粉样纤维的形成. 不同的拥挤剂会影响蛋白质聚合通路和由此产生的粉样蛋白结构.

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