核受体核心压缩剂1是清细胞细胞癌的潜在诊断和预后生物标志物
Lu-Ri Bao1,2, Wu-Niri Gao3, Xi-Feng Wang4
1Department of Pathology, School of Basic Medicine, Inner Mongolia Medical University, Hohhot, PR China.
Scientific reports
|January 27, 2026
概括
核受体核心压缩剂1 (NCOR1) 在清细胞细胞癌 (ccRCC) 中下调,影响细胞循环和免疫透. 较低的NCOR1表达和较高的甲基化与ccRCC的预后和生存率不佳相关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 清细胞细胞癌 (ccRCC) 是一个重要的全球健康问题.
- 确定可靠的ccRCC诊断和预后生物标志物对于改善患者的治疗结果至关重要.
研究的目的:
- 研究核受体核心压缩剂1 (NCOR1) 作为ccRCC中的诊断和预后生物标志物的作用.
- 在ccRCC中探索NCOR1表达,瘤进展,免疫微环境和患者存活率之间的关联.
主要方法:
- 癌症基因组图谱和基因表达总汇数据集的分析.
- 临床ccRCC样本的免疫组织化学染色.
- 功能丰富分析,相关性分析,DNA甲基化分析和生存分析.
主要成果:
- 在ccRCC组织中,NCOR1表达显著下调,与其他11种瘤类型相关.
- NCOR1下调与细胞周期激活,改变免疫细胞透和免疫检查点基因表达相关.
- 减少NCOR1表达和其基因甲基化增加与晚期瘤阶段,组织学等级差,和不良预后 (OS,DSS,PFI) 相关.
- NCOR1显示出诊断值 (AUC=0.673),并作为ccRCC预后的独立保护因子.
结论:
- NCOR1下调是ccRCC进展的关键事件,影响细胞周期和免疫逃避.
- 对于ccRCC患者来说,NCOR1表达水平和DNA甲基化状态是有价值的预后指标.
- NCOR1具有作为ccRCC的诊断生物标志物和治疗点的潜力.
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