冠状动脉样硬化的机制,精确疗法和技术前沿:综合性综述
Zi-Xuan Qiu1, Ruo-Yu Wang1, Yi Zhang1
1Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Acta pharmacologica Sinica
|January 27, 2026
概括
精准医学的进步,包括多组学和人工智能,完善了冠状动脉疾病风险评估. 基因编辑和纳米技术等新型疗法提供了个性化的动脉样硬化管理,旨在减少全球心血管负担.
科学领域:
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
背景情况:
- 冠状动脉样硬化仍然是一个主要的全球健康问题,由脂质失调和炎症等复杂机制驱动.
- 目前的治疗方法留下了显著的残留风险,特别是在遗传倾向或服务不足的人群中.
研究的目的:
- 审查目前对冠状动脉样硬化机制的理解.
- 探索新兴的精准医学策略和新的治疗干预措施.
主要方法:
- 综合当代关于疾病机制的研究.
- 分析精准医学,多组学和成像技术的进步.
- 审查新的治疗目标和技术.
主要成果:
- 精准医学工具 (例如,单细胞转录组学,多基因风险评分,AI斑块分析) 提高了心血管风险分层.
- 新兴疗法包括针对PCSK,炎症途径,基于细胞的再生,CRISPR-Cas9基因编辑,纳米技术和肠道微生物群调节.
结论:
- 创新的方法有望实现个性化的动脉样硬化管理和持久的脂质降低.
- 必须解决可访问性,健康平等和实施方面的挑战,以实现广泛的临床采用.
- 整合多式联络数据分析与向治疗意味着精确心脏病学的新时代,以减少冠状动脉疾病的负担.
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