基于磁性纳米粒子瘤学的通用化血管模型:几何和微流体特性
Daniel Fleischhauer1,2, Samuel Schlicht3, Dietmar Drummer3,4
1Institute of Polymer Technology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Am Weichselgarten 10, 91058, Erlangen, Germany. daniel.fleischhauer@fau.de.
超偏磁铁氧化物纳米颗粒 (SPIONs) 可以通过磁力引导以提供向药物. 较低的流量增强了SPION再分配,而更高的,不稳定的流量阻碍了血管模型中的磁性控制.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 流体动力学 流体动力学
背景情况:
- 超偏磁铁氧化物纳米粒子 (SPIONs) 在瘤学中越来越多地用于向药物输送.
- 有效的基于SPION的疗法需要了解血管内的纳米粒子行为,包括几何,水力动力学和粘附.
- 开发可复制的血管模型对于测试纳米粒子输送系统至关重要.
研究的目的:
- 为了研究血管几何和流量条件对SPIONs磁转向的影响.
- 为可复制的SPION传播研究创建通用,可转移的血管模型.
- 评估变化的磁转向,SPION度和流量对SPION沉积的影响.
主要方法:
- 使用立体石版增材制造,制造各种直径和分支顺序的流体血管模型.
- 在不同的磁性方向盘条件下,SPION度和流量下对SPION传播的实验测试.
- 在现场进行光学测量和现场扫描电子显微镜,以分析SPION的行为和分布.
主要成果:
- 水力动力学效应显著地影响了SPIONs的磁性方向性,这取决于流量状态.
- 降低的流速促进了层状流动,使SPIONs在0.35 T的有限磁性重新分配成为可能.
- 增加的流速和不稳定的流量会损害磁性控制的SPION沉积,减少局部控制.
结论:
- 血管几何和流动动力学极大地影响了SPIONs的定量磁转向.
- 血管模型中的低流量条件增强了局部粒子停留时间和SPION再分配.
- 研究结果强调了流量条件对于优化基于SPION的向治疗在瘤学中的重要性.
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