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相关概念视频

Neurons: The Axon01:21

Neurons: The Axon

7.2K
Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment....
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Initiation of Translation02:33

Initiation of Translation

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Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
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Initiation of Translation02:33

Initiation of Translation

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8.1K
Subliminal Perception01:15

Subliminal Perception

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Subliminal perception refers to the processing of sensory information that occurs below the level of conscious awareness. Researchers study subliminal perception by presenting a stimulus, such as a word or image, very quickly, typically around 50 milliseconds. This rapid presentation is often followed by another stimulus, such as a pattern of dots or lines, which blocks further mental processing of the initial stimulus. As a result, if participants cannot identify the initial stimulus better...
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Factors Affecting Perception01:25

Factors Affecting Perception

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Perception is influenced by perceptual set, context, motivation, and emotion. Perceptual set, or perceptual expectancy, refers to the tendency to perceive things in a particular way, influenced by previous experiences and expectations. This phenomenon affects the interpretation of stimuli, creating a set of mental tendencies and assumptions that impact sensory perceptions of sound, taste, touch, and sight.
An illustrative example of a perceptual set is the scenario where an airline pilot told...
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Perception01:28

Perception

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Perception is a fundamental psychological process that enables individuals to organize, interpret, and consciously experience sensory information. This process is crucial for understanding and interacting with the world around us. It includes both bottom-up and top-down processing, each playing a distinct role in how we perceive our environment.
Bottom-up processing begins at the sensory level, where receptors detect external environmental stimuli. These could include the tactile sensation of...
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相关实验视频

Updated: Jan 29, 2026

Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments
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轴突初始段相关的微质细胞调节神经元活动和视觉感知.

Yaping Wang1, Qiushi Wang1, Chen Gao1

  • 1Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence; State Key Laboratory of Multi-organ Injury Prevention and Treatment; Key Laboratory of Mental Health of the Ministry of Education; Guangdong Province Key Laboratory of Psychiatric Disorders; Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases; Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders; Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.

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概括
此摘要是机器生成的。

神经元轴突初始段 (AISs) 附近的微细胞通过K+释放来调节神经元的发射. 这种相互作用对于小鼠的视觉感知和认知功能至关重要.

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In vivo Visualization of Synaptic Vesicles Within Drosophila Larval Segmental Axons
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Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM
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相关实验视频

Last Updated: Jan 29, 2026

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In vivo Visualization of Synaptic Vesicles Within Drosophila Larval Segmental Axons
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科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 微质细胞,大脑的先天免疫细胞,与神经元相互作用,但机制尚不清楚.
  • 具体的微质神经元功能相互作用在很大程度上是未知的.

研究的目的:

  • 为了识别和描述新的微质-神经元功能相互作用.
  • 阐明这些相互作用在神经元活动和视觉感知中的作用.

主要方法:

  • 在新皮质中识别与AIS相关的微质.
  • 神经元活动的电生理记录.
  • 在视觉刺激期间的体内两光子成像.
  • 对视觉歧视的行为测试.

主要成果:

  • 与AIS相关的微质脱极化并通过THIK-1释放K+,促进神经元的激发.
  • 视觉刺激会诱导微质脱极化和K+释放,增强神经元的反应.
  • 破坏AIS-微质相互作用会损害神经元活动和视觉歧视.

结论:

  • 确定了微质和刺激神经元AIS之间的新功能相互作用.
  • 这种通过微质K+释放的相互作用,对于调节神经元活动和视觉处理至关重要.
  • 这些发现突出了微质细胞参与高阶大脑功能的新机制.