心率变化和MOXO d-CPT关系在儿童注意力缺陷多动性障碍
Sultan Tarlacı1, Yaren Kaya Topal2
1Medical Faculty, Department of Neurology and Neuroscience, Üsküdar University, İstanbul, Turkey. sultan.tarlaci@uskudar.edu.tr.
患有ADHD的儿童表现出心率变化 (HRV) 的改变. 具体来说,较低的VLF功率和较高的SNS指数在ADHD中表明同情神经系统的变化与较差的认知任务性能有关.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 心理学 心理学 心理学
背景情况:
- 注意缺陷多动性障碍 (ADHD) 是一种流行的神经发育障碍.
- 自主神经系统功能障碍,特别是心率变化 (HRV),在ADHD中越来越多地被认可.
- 了解ADHD中的HRV可以提供对疾病病理生理学的见解,并告知潜在的生物标志物.
研究的目的:
- 调查ADHD儿童与通常发育的对照儿童之间静止状态心率变化 (HRV) 的差异.
- 在患有ADHD的儿童中,确定与计算机化注意力任务 (MOXO d-CPT) 的表现相关的特定HRV指标.
主要方法:
- 一项涉及52名6至12岁儿童的病例控制研究,通过DSM-5标准证实了ADHD诊断,并排除了并发症.
- 休息状态HRV用极地H10装置记录了5分钟.
- 分析包括时间域 (SDNN,RMSSD),频域 (VLF,LF,HF) 和非线性HRV指数,以及MOXO d-CPT性能指标.
主要成果:
- 与表现良好组相比,在MOXO d-CPT上表现较差的ADHD组显示出明显较低的非常低频 (VLF) 功率.
- 交感神经系统 (SNS) 指数在疲弱过度活跃子组显著更高,表明交感激活增加.
- 观察到SDNN和RMSSD差异的趋势,但没有达到统计学意义,这表明副交感参与最小.
结论:
- VLF功率和SNS指数成为与ADHD冲动性和多动性表现相关的最强大的HRV指标.
- 这些发现表明,特定的HRV变化,特别是与同情活动相关的变化,与ADHD的认知表现缺陷有关.
- 需要进行进一步的纵向研究,以探索HRV在监测ADHD治疗反应及其对认知子域的特异性的有用性.
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