在身体活跃的女性中,月经周期和荷尔蒙避孕药阶段的雄激素特征的变化
Vera M Salmi1, Ritva S Mikkonen2, Ida E Löfberg2
1Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland. vera.m.salmi@jyu.fi.
BMC women's health
|January 28, 2026
概括
女性的雄激素水平在月经周期 (MC) 和荷尔蒙避孕药 (HC) 期间波动. 这项研究调查了这些雄激素变化在不同阶段的自然月经,宫内节育器和组合HC用户.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 激素研究 研究 激素研究
背景情况:
- 女性性激素度在整个月经周期 (MC) 中都会发生变化.
- 激素避孕药 (HC) 通常会抑制下丘脑-垂体-卵巢轴,降低内源性雌激素 (E2) 和孕 (P4).
- 在MC和HC阶段,雄激素度的变化未得到充分研究.
研究的目的:
- 为了研究和比较MC和HC阶段的雄激素度波动.
- 了解不同避孕方法对雄激素水平的影响.
主要方法:
- 在四个时间点对健康,活跃的雌性血清样本进行横截面分析.
- 参与者包括自然月经 (NM,n=36),激素宫内器械 (IUD,n=12) 和组合HC (CHC,n=25) 用户.
- 测试中的激素包括E2,P4,FSH,LH,总 (tT),自由 (fT),SHBG,DHEA和DHEA-S.
主要成果:
- 在NM中,tT,ft和DHEA在排卵阶段较高;与出血相比,DHEA-S在卵泡中期较高.
- 在IUD使用者中,tT度波动很大,在周期中期达到峰值.
- 在CHC使用者中,E2,P4,TT,FT,DHEA和DHEA-S度在HC阶段保持稳定.
结论:
- 在自然的月经周期中,雄激素水平呈现出明显的波动.
- 荷尔蒙避孕药,特别是联合HC,稳定雄激素度.
- 了解这些激素变化对于生理学研究和潜在的临床应用至关重要.
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