卵巢T细胞淋巴瘤在患有慢性蛋白质丧失肠病的狗身上
Jacob Kvesel Mortensen1, Emil Wikström2, Norbert van de Velde2
1Gothenburg Animal Hospital Evidensia, Produktvägen 5, 435 33, Mölnlycke, Sweden. jacob.mortensen@evidensia.se.
Acta veterinaria Scandinavica
|January 28, 2026
概括
卵巢T细胞淋巴瘤是一种罕见的犬类恶性瘤. 这一案例凸显了蛋白质丧失肠病症的狗的诊断挑战,强调了需要考虑瘤的必要性.
科学领域:
- 兽医瘤学 兽医瘤学
- 狗淋巴瘤研究研究 狗淋巴瘤研究
- 其他外性恶性瘤.
背景情况:
- 淋巴瘤在狗中很常见,但卵巢T细胞淋巴瘤非常罕见.
- 狗淋巴瘤通常来自B细胞;T细胞类型往往表明预后更差.
- 失去蛋白质的肠道病变 (PLE) 会导致狗的低albuminemia,与淋巴管切开症或肠道病变有关.
研究的目的:
- 报告一种罕见的卵巢T细胞淋巴瘤病例.
- 讨论与 extranodal 淋巴瘤相关的诊断挑战.
- 探索慢性炎症,免疫抑制和淋巴瘤发展之间的潜在联系.
主要方法:
- 评估了一只10岁的迷你狗狗,患有慢性腹,炎和低蛋白血症.
- 怀疑PLE的初始治疗包括免疫抑制剂;后来确定了卵巢质量.
- 卵巢T细胞淋巴瘤的诊断通过细胞学,组织病理学和免疫组织化学证实.
主要成果:
- 这只狗最初对PLE的免疫抑制疗法有反应.
- 一个被诊断为T细胞淋巴瘤的卵巢质量,14个月后发展.
- 尽管最初的稳定性,淋巴瘤扩散到多个器官,导致安乐死.
结论:
- 狗的外节淋巴瘤存在诊断困难,特别是当模仿其他疾病如PLE时.
- 在犬患有慢性蛋白质丧失肠病的病例中,应怀疑新生病.
- 慢性炎症和免疫抑制治疗在狗淋巴发育中的作用需要进一步调查.
相关概念视频
Ovarian Cycle
3.7K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
3.7K
Chronic Pharyngitis
11.7K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
11.7K
Hormonal Control of the Ovarian Cycle
6.8K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
6.8K
Chronic Pancreatitis I: Introduction
727
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
727
Protein and Protein Structure
87.4K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
A protein's shape is critical to its function. For example, an enzyme...
87.4K
Protein Dynamics in Living Cells
2.7K
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.7K


