围围假肢关节感染的生物标志物研究的全球趋势:一个文献计量分析
1Department of Orthopedics, Beijing Luhe Hospital, Capital Medical University, Beijing, 101149, China.
Arthroplasty (London, England)
|January 28, 2026
概括
周围假肢关节感染 (PJI) 的诊断是具有挑战性的. 研究表明,从血清标记物转移到像α-defensin和calprotectin这样的突试验,机器学习和分子诊断的新兴作用.
科学领域:
- 生物标志物研究的研究.
- 医学诊断 医学诊断 医学诊断
- 图书统计学 图书统计学
背景情况:
- 周围假肢关节感染 (PJI) 诊断存在重大挑战,缺乏单一的确定的生物标志物.
- 突,血清和分子测定方面的进步需要对全球生物标志物研究的全面概述.
研究的目的:
- 提供2011-2024年间围假肢关节感染 (PJI) 生物标志物研究的数据驱动映射.
- 在PJI诊断中确定主要的主题转变和有影响力的研究领域.
- 评估研究趋势对临床翻译的影响.
主要方法:
- 科学网络核心数据 (2011-2024) 的图书统计分析,用于PJI诊断和生物标志物研究.
- 使用VOSviewer,CiteSpace和Bibliometrix进行网络,关键字共同出现和共同引用分析.
- 审查了高影响力的研究和共识指导方针,以将发现置于背景.
主要成果:
- 在PJI生物标志物出版物显著增加,中国和美国的显著贡献.
- 确定了关键的研究机构和期刊,其中"关节塑造学杂志"发表了最多的研究.
- 记录了从传统血清标记物到突试验 (α-defensin,白细胞雌激酶) 和先进技术 (calprotectin,机器学习,微流体学,分子诊断) 的专题演变.
结论:
- 在美国,中国和欧洲机构的推动下,PJI生物标志物研究迅速扩大.
- 关键的研究主题包括突α-defensin,calprotectin,机器学习和下一代测序.
- 未来的进步需要多中心验证,测试标准化,集成到诊断算法,并加强合作,以改善PJI诊断.
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