在比利时5岁以下儿童中持续高水平的侵入性Streptococcus pyogenes感染:5岁以下的比利时儿童:探索不同的促成因素
Laura Cornelissen1, Frederik De Keersmaeker1, Sien De Koster2
1From the Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.
The Pediatric infectious disease journal
|January 28, 2026
概括
在比利时的年幼儿童中,侵袭性A组链球菌 (iGAS) 感染在流行病后仍然很高. 麻疹病毒的循环,而不是其他呼吸道病毒,与iGAS的增加相关,这表明多因素原因.
科学领域:
- 儿童传染病 儿童传染病
- 流行病学 流行病学
- 微生物学 微生物学
背景情况:
- 侵袭性A组链球菌 (iGAS) 感染的国际上升发生在2022年底-2023年初.
- 之前的报道只集中在流行后的时期,导致因素不清楚.
研究的目的:
- 调查比利时五岁以下儿童iGAS的流行病学.
- 评估共传播病毒感染对iGAS发病率的影响.
主要方法:
- 2014年1月至2024年12月的比利时实验室数据分析.
- 在季节性调整后,共同整合分析以评估iGAS病例与病毒性疾病 (水,RSV,流感) 之间的关系.
主要成果:
- 从2022年6月起,iGAS病例激增,在2023年4月达到顶峰,并持续升高至2024年初.
- 人口免疫力下降本身并不能解释iGAS的激增.
- 麻疹发病率,但不是RSV或流感,与IGAS水平有很强的相关性.
- 连续的主导iGAS基因型 (emm12, emm1, emm3) 表明复杂的传播动态.
结论:
- 在非药物干预停止后,IGAS感染在高水平下持续了长达两年.
- iGAS的增加是多因素的,而水联合循环是一个重要的因素.
- 持续,高质量的监测对于监测iGAS趋势至关重要.
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