在日本医院的废水中进行的首次多重设施抗菌监测揭示了时空趋势和源特定的环境负荷
Takashi Azuma1,2, Ai Tsukada3, Naoki Fujii3
1Department of Pharmaceutical Sciences, Osaka Medical and Pharmaceutical University, Takatsuki 569-1094, Japan.
Antibiotics (Basel, Switzerland)
|January 28, 2026
概括
医院的废水显著提高了抗菌药物的度,特别是levofloxacin,vancomycin和ampicillin. 有针对性的污染控制对于管理抗微生物药物耐药性 (AMR) 至关重要.
科学领域:
- 环境科学 环境科学
- 环境化学环境化学
- 公共卫生 公共卫生
背景情况:
- 医院是城市废水中抗菌素的重要来源.
- 缺乏以前对医院抗菌药物排放情况的全面评估.
- 抗微生物污染对环境和公共健康构成风险.
研究的目的:
- 调查和量化医院废水中的残留抗微生物度.
- 为了比较医院和非临床废水源之间的抗微生物特征.
- 为了确定抗微生物药物排放的设施特定和时间模式.
主要方法:
- 在日本,对来自五家普通医院和一家商业设施的废水进行了多个地点的调查.
- 12周的抽样时间 (2023年12月至2024年3月).
- 使用高通量分析对来自多个类别的15种抗微生物药物的量化.
主要成果:
- 与非临床场所相比,医院的废水始终显示某些抗微生物药物的度更高 (利沃素,万科米素,安比西林).
- 具体设施和时间模式表明与当地处方做法有很强的相关性.
- 对一些化合物 (克拉里思罗米,米诺环素) 观察到来自医院和商业来源的双重贡献.
结论:
- 调查结果强调了对抗微生物污染源有针对性的监测的必要性.
- 实施有效的抗微生物污染控制战略的建议.
- 为扩大对抗微生物药物耐药性 (AMR) 的监测和环境政策提供信息提供基础.
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