Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Peptide Bonds02:43

Peptide Bonds

82.8K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
82.8K
Resistivity01:22

Resistivity

4.5K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.5K
Resistance01:19

Resistance

5.9K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.9K
Equivalent Resistance01:16

Equivalent Resistance

976
In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
976
Resistance and Conductance01:25

Resistance and Conductance

509
A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
509
Rolling Resistance01:21

Rolling Resistance

640
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
640

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Synergistic Potential of Plant Alkaloids and Intragenic Antimicrobial Peptides in Treating Multidrug-Resistant Infectious Diseases.

Antibiotics (Basel, Switzerland)·2026
Same author

Cyclotides from Plants Driving the Next Generation of Antibacterial Agents.

Antibiotics (Basel, Switzerland)·2026
Same author

Unraveling the mechanism of action of the PepGAT peptide against Candida albicans through proteomics approaches.

Scientific reports·2026
Same author

Computer-Aided Design of <i>Plasmodium chabaudi</i>-Derived Peptides with Dual Antibiofilm and Anti-inflammatory Activities.

ACS medicinal chemistry letters·2026
Same author

Cellular senescence in the dental pulp and its implications for endodontics: a scoping review.

Clinical oral investigations·2026
Same author

Harnessing AI for Antimicrobial Peptide Innovation against Multidrug Resistance.

JACS Au·2026

相关实验视频

Updated: Jan 29, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.9K

类似于cathelicidin的用于抵抗Acinetobacter baumannii的控制

Elizabete de Souza Cândido1,2, Danieli Fernanda Buccini2, Elizangela de Barros Miranda2

  • 1Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília 71966-700, DF, Brazil.

Antibiotics (Basel, Switzerland)
|January 28, 2026
PubMed
概括

蛇毒BotrAMP14和CrotAMP14表现出强大的抗菌和抗菌膜活性,对抗药物耐药的皮肤病原体. 这些抗微生物为治疗具有挑战性的伤口感染提供了有希望的替代方案.

关键词:
抗微生物是一种抗微生物.生物膜是一种生物膜.这是一种类似于cathelicidin的药物.皮肤感染 皮肤感染.皮肤 皮肤 皮肤

更多相关视频

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System
07:59

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System

Published on: April 25, 2025

1.2K
The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides
08:37

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides

Published on: November 2, 2021

2.5K

相关实验视频

Last Updated: Jan 29, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

9.9K
Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System
07:59

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System

Published on: April 25, 2025

1.2K
The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides
08:37

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides

Published on: November 2, 2021

2.5K

科学领域:

  • 抗微生物耐药性研究的研究.
  • 类治疗药物 类治疗药物
  • 伤口感染管理管理

背景情况:

  • 抗菌素耐药性 (AMR) 构成全球健康威胁,特别是在伤口感染中.
  • 像Acinetobacter baumannii这样的多药耐药病原体形成生物膜,使治疗复杂化.
  • 抗微生物 (AMP) 提供了一种具有降低抗性潜力的新型治疗方法.

研究的目的:

  • 为了评估蛇毒衍生的cathelicidin类对抗多药耐药细菌.
  • 评估所选的抗菌,抗菌膜和体内疗效.
  • 调查这些的安全性,包括溶血和细胞毒性作用.

主要方法:

  • 确定最小抑制度 (MIC),最小杀菌度 (MBC) 和最小生物膜抑制度 (MBIC).
  • 进行了杀时动力学,溶血活性和细胞毒性测试.
  • 使用小鼠皮肤伤口感染模型来评估体内疗效和安全性.

主要成果:

  • 对抗耐药细菌的浮游生物和生物膜形式表现出强烈的活性 (MIC/MBC:0.78-25μM;MBIC:1.56-12.5μM).
  • 在小鼠伤口模型中,BotrAMP14和CrotAMP14表现出快速杀菌作用和显著的体内疗效.
  • 体没有表现出血解活性和低细胞毒性,这表明其安全性较好.

结论:

  • BotrAMP14和CrotAMP14是有效的局部抗微生物药物,可以对抗多药性皮肤感染.
  • 这些代表了传统抗生素对挑战性伤口感染的有希望的替代品.
  • 这些发现解决了对抗生素耐药性病原体的新疗法的迫切需要.