相关实验视频
Updated: Jan 29, 2026

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
24.2K
上腺静脉采样有助于区分17-基孕超分泌上腺皮层腺瘤与非经典的21-基酶缺乏症
Ruojun Qiu1, Tian Yang2, Chengxin Shang1
1Department of Endocrinology, The Affiliated Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.
Diagnostics (Basel, Switzerland)
|January 28, 2026
概括
一个罕见的分泌17-基孕 (17-OHP) 的上腺腺瘤在一个经常流产的妇女身上被发现. 这一发现扩大了17-OHP升高的差异诊断范围,超出了先天性上腺增生症 (CAH).
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 血清17-基孕 (17-OHP) 的升高通常与先天性上腺增生 (CAH) 相关.
- 一个反复流产的案例促使人们对17-OHP升高的原因进行调查.
- 这个案例挑战了17-OHP升高的常规诊断方法.
研究的目的:
- 为了呈现一个17-OHP分泌上腺腺瘤的病例.
- 强调在高17-OHP的差异诊断中考虑上腺瘤的重要性.
- 为了探索潜在的病原遗传机制.
主要方法:
- 整体外体测序 (WES) 排除CAH的遗传原因.
- 用ACTH刺激测试来评估上腺反应.
- 上腺静脉采样 (AVS) 以定位荷尔蒙过分分泌.
- 上腺体质量的组织病理学和转录学分析.
主要成果:
- 一名33岁的女性出现了反复流产和升高的17-OHP.
- 基因检测和荷尔蒙资料排除了非经典的21-基酶缺乏症 (NC-21OHD).
- AVS证实左上腺17-OHP的高分泌,导致对上腺腺瘤的诊断.
- 手术后17-OHP的正常化和组织病理学证实了瘤的性质.
- 转录组分析表明微RNA和PI3K-Akt通路的参与.
结论:
- 一种17-OHP分泌的上腺腺瘤是17-OHP升高的关键差异诊断.
- 包括AVS在内的多式诊断技术对于定位功能性上腺瘤至关重要.
- 表观遗传失调可能在这些瘤的发展中起作用.
相关概念视频
Anatomy of the Adrenal Glands
4.7K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
4.7K
Adrenal Gland Disorders
3.3K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.3K
Hormones of the Adrenal Glands
5.4K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
5.4K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
2.9K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
2.9K
Classical Conditioning
2.1K
Associative learning, a core principle in behavioral psychology, involves forming connections between events and facilitating learned responses. This concept is vividly illustrated by classical conditioning, a process extensively studied by the Russian physiologist Ivan Pavlov. Pavlov's pioneering research on dogs' digestive systems led to the discovery that behaviors can be learned through association, laying the groundwork for classical conditioning.
Ivan Pavlov observed that dogs...
Ivan Pavlov observed that dogs...
2.1K
Venous Return
12.2K
The circulatory system plays a crucial role in ensuring the optimal functioning of the human body. One of its critical components is venous return - the process that completes the blood circulation cycle. This article will delve into the concept of venous return, how it works, and its significance to our health.
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
What is Venous Return?
Venous return refers to the rate at which blood flows back to the heart from the body's peripheral veins. It's an integral part of the circulatory system...
12.2K

