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基于纸张的微流体芯片用于家用护理点核酸检测:应用和挑战

Hao Liu^1,2, Yuhan Jia^1,2, Yitong Jiang^1,3

¹Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China.

Diagnostics (Basel, Switzerland)

|January 28, 2026

概括

基于纸张的微流体芯片 (μPAD) 为家庭核酸测试提供了低成本的便携式解决方案. 本综述强调了用于传染病查的提取,放大和检测整合方面的进展和挑战.

科学领域:

生物医学工程生物医学工程
分子诊断学分子诊断学
照顾点检测检测照顾点检测

背景情况:

对于在家进行分子诊断的需求在个性化医学和公共卫生方面不断增加.
基于纸张的微流体芯片 (μPAD) 是低成本,便携式核酸测试的前景.
目前的μPAD在核酸提取,放大稳定性和信号读出标准化方面面临着挑战.

研究的目的:

系统地审查在家用核酸测试中μPADs的最新进展.
专注于提取-放大-检测系统的整合.
分析关键技术和应用案例的发展趋势.

主要方法:

对家用分子诊断的μPAD最近研究的综述.
分析材料工程,流体控制,信号传导和智能读出.
检查在传染病查中的应用案例.

主要成果:

在将μPAD集成到核酸测试中取得了显著进展.
材料工程和智能读取等关键技术正在进步.
应用案例显示了快速传染病查的潜力.

结论:

μPAD显示出家庭分子诊断的巨大潜力,但仍然存在挑战.
优化途径包括标准化制造,冷链独立存储和人工智能辅助解释.
本次审查为开发未来家用分子诊断系统提供了一个框架.

关键词:

传染病诊断传染病诊断传染病诊断核酸测试核酸测试试验基于纸张的微流体 (μPADs)医疗点检测 (POCT) 是指在医疗中心进行的检测.

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