三种不同的结合剂对结肠镜准备的有效性的比较:一个多中心随机临床试验
Saša Štupar1, Borut Štabuc1,2, Bojan Tepeš3
1Department of Gastroenterology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Diagnostics (Basel, Switzerland)
|January 28, 2026
概括
三种肠道制备方法,Moviprep与Donat Mg和两个Plenvu变体,在结肠镜检查中显示出类似的高疗效和耐受性. 所有选项都是安全的,并且非常适合在结直肠癌查中的常规临床使用.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠癌查 结肠直肠癌查
- 内镜检查是指内镜检查.
背景情况:
- 高质量的肠道准备对于准确的结肠镜检查至关重要,结肠直肠癌查的主要方法.
- 将Moviprep等常见的肠道制备方案与Donat Mg和Plenvu进行比较,对于优化临床实践至关重要.
研究的目的:
- 为了比较Moviprep与Donat Mg,Plenvu和Plenvu与Donat Mg的疗效和耐受性,用于结肠镜检查.
- 评估三种不同的肠道制备方案的肠道清洁,病变检测率和患者报告的结果.
主要方法:
- 一个随机的,多中心的,盲目的临床试验,涉及300名接受选择性结肠镜检查的成年患者.
- 患者被分配到三个肠道制备组之一:Moviprep与Donat Mg,Plenvu或Plenvu与Donat Mg.
- 通过波士顿肠道准备量表 (BBPS) 评估肠道清洁性;通过聚合物检测率 (PDR) 和腺瘤检测率 (ADR) 检测损伤;通过患者问卷评估耐受性.
主要成果:
- 这三种方案都实现了高肠道准备充分性 (≥95%) 在BBPS分数,PDR或ADR中没有显著差异.
- 不良影响在各组中都是轻微的和可比的,口渴和胀气是最常见的.
- 在所有方案中,患者的满意度和重复药物的意愿都很高,没有统计学上显著的差异.
结论:
- 使用Donat Mg的Moviprep,使用Donat Mg的Plenvu和使用Donat Mg的Plenvu是有效,安全和耐受良好的肠道制备选择,符合质量标准.
- 虽然所有方案都适合常规使用,但由于该研究并未为等效性提供动力,因此应根据患者个体因素进行选择.
- 建议进一步考虑患者的特征和偏好,以选择最佳的肠道准备方案.
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