酸对肠道屏障功能障碍和基于犬细胞模型的炎症激活的保护作用
Alma Virág Móritz1,2, Orsolya Farkas1,2, Ákos Jerzsele1,2
1Department of Pharmacology and Toxicology, University of Veterinary Medicine Budapest, 1078 Budapest, Hungary.
Animals : an open access journal from MDPI
|January 28, 2026
概括
酸 (HA) 补充剂可以支持狗的肠道健康. 这项研究发现,HA保留了肠道屏障功能,并减少了犬细胞的炎症,这表明它有潜力治疗慢性肠道病变.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道屏障对于营养吸收和防止病原体转移至关重要.
- 狗的障碍障碍功能与慢性炎症性肠道病变,失生症和免疫失调有关.
- 胺酸 (HA) 显示出对肠道健康的潜力,但需要进一步的机制性调查.
研究的目的:
- 为了评估基于酸 (HA) 的补充剂对狗肠道上皮细胞和免疫细胞的影响.
- 在体外研究HA对表皮屏障完整性和炎症反应的影响.
- 探索HA作为一种潜在的营养药物,用于犬的肠道健康.
主要方法:
- 使用了结合犬肠上皮细胞 (IPEC-J2) 和外周血液单核细胞 (PBMCs) 的体外模型.
- 通过 FD4 准细胞流量评估上皮质屏障完整性.
- 在基底和脂聚糖 (LPS) 刺激条件下测量了反应性氧物种和促炎性细胞因子 (TNF-α,IL-6) 生产.
主要成果:
- 酸 (HA) 治疗维持了上皮质屏障的完整性.
- HA显著降低了脂聚糖 (LPS) 诱导的促炎性细胞因子 (TNF-α,IL-6) 的产生.
- 在犬类细胞模型中,HA证明了对LPS诱导的炎症的保护作用.
结论:
- 酸 (HA) 保持肠上皮质屏障功能,并调节狗体外模型中的炎症反应.
- 这些发现支持进一步研究HA作为支持慢性肠道病变的狗肠道健康的营养药.
- HA需要作为对影响肠道的犬类炎症状况的辅助疗法进行研究.
关键词:
在IPEC-J2细胞中.这就是PBMCs.狗类模型 狗类模型慢性肠道病变 慢性肠道病变酸是指酸中的一种.这是一种炎症炎症炎症炎症.肠道屏障 肠道屏障 肠道屏障脂多糖 (LPS) 是一种脂多糖.氧化应激是一种氧化应激.更多相关视频
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