四种胃足动物物种离子受体的全基因组表征揭示了与饮食相关的功能分歧的进化模式
Gang Wang1,2,3, Yi-Qi Sun1,2,3, Fang Wang1,2,3
1Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Yancheng Teachers University, Yancheng 224051, China.
Animals : an open access journal from MDPI
|January 28, 2026
概括
这项研究揭示了类受体 (IR) 在胃类动物中如何进化,显示了某些物种的扩张和在嗅觉和饮食适应中保留的作用. 这些发现揭示了IR在各种养生态中的演变和功能.
科学领域:
- * 进化生物学 进化生物学
- * 分子遗传学 分子遗传学
- * 神经科学是一门神经科学.
背景情况:
- * 离子体受体 (IRs) 是离子体谷氨酸受体 (iGluRs) 的一个子家族,对于检测环境线索和影响食等行为至关重要.
- * 了解与养生态有关的IR进化对于理解它们的适应性作用至关重要.
研究的目的:
- *研究各种饮食的胃类动物中IR和iGluR的进化模式和分子特征.
- * 探索红外扩张,基因复制和养生态之间的关系.
- * 分析跨类物种的IRs的功能专业化和进化约束.
主要方法:
- *在四种有着不同的饮食的胃类动物物种中,全基因组识别了IR和iGluR.
- * 遗传学分析以确定进化关系和基因重复事件.
- *蛋白与蛋白相互作用网络分析,结构分析,选择压力评估,对线性分析和定量PCR (qPCR) 用于基因表达.
主要成果:
- * 在 * 巴比伦亚罗拉塔 * 中观察到IR的显著扩张,表明血统特定的多样化.
- * 遗传学分析显示IRs与GluD聚集在一起,这表明基因复制后的早期功能分歧.
- * *IR25b*表现出并列重复和蛋白质-蛋白质相互作用网络中的中心作用;IR表现出酸性/基本性,表明功能专业化;在物种之间确定了保存的域和动图.
- *大多数IR都经过了净化选择,除了Pomacea canaliculata,它显示了放松的约束.
- *保存的基因和IRs的组织特异表达得到证实.
结论:
- * 这项研究阐明了类IRs的分子特征和进化轨迹.
- * 发现突出了IRs在胃类动物嗅觉和适应不同养生态中的潜在作用.
- * IR 扩张和多样化与生态因素,特别是饮食有关.
相关概念视频
What is Evolutionary History?
43.3K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
43.3K
Enzyme-linked Receptors
86.5K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.5K
Evolutionary Relationships through Genome Comparisons
7.0K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.0K
Genome Size and the Evolution of New Genes
9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K
Genome-wide Association Studies-GWAS
15.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.6K
Transducer Mechanism: Enzyme-Linked Receptors
4.0K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
4.0K


