作为LPS的补充模型,Salmonella enterica用于断奶小猪的免疫应激:系统和肠道变化
Li Dong1,2, Zhiyan Liu1, Wenxi Li1
1Department of Animal Science and Technology, College of Animal Science and Technology, Yangzhou University, No. 48 of East Wenhui Road, Yangzhou 225009, China.
Animals : an open access journal from MDPI
|January 28, 2026
概括
小猪口腔沙门氏菌肠道 (SE) 感染导致比脂多糖 (LPS) 模型更严重的免疫应激和肠道损伤. SE挑战为研究提供了更准确的自然细菌感染表征.
科学领域:
- 兽医免疫学 兽医免疫学
- 疾病的动物模型.
- 胃肠道病理 胃肠道病理
背景情况:
- 脂多糖 (LPS) 是一个常见的诱导免疫应激在断奶小猪.
- LPS模型不能完全复制活细菌感染的复杂病理生理学.
- 需要更多生理上相关的猪免疫应激模型.
研究的目的:
- 建立和评估口服沙门氏菌 (SE) 挑战模型,用于断奶小猪.
- 为了比较SE感染的病理生理影响与LPS诱导的免疫应激.
- 评估SE模型是否适合模仿天然沙门氏菌感染.
主要方法:
- 40只被断奶的小猪被分为对照组,LPS和三个口服SE剂量组.
- 测量包括平均每日增益,直肠温度,结肠长度,血清细胞因子和CD4+/CD8+T细胞比率.
- 检查了肠道组织的病理变化,包括状形态和杯状细胞数量.
主要成果:
- LPS和SE都减少了平均每日增长;只有SE减少了结肠长度.
- SE感染引发了更严重的肠道病理,包括孔和失组织.
- 与LPS相比,SE挑战导致更强大和持续的促炎细胞因子反应.
结论:
- 口腔SE挑战提供了一个比LPS更全面和严重的免疫应激反应.
- 该SE模型有效地模仿了断奶小猪的天然沙门氏菌感染.
- 该模型是研究肠道疾病和评估猪干预措施的宝贵工具.
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