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来自植物的生物活性化合物的进展及其在阿尔茨海默病中的应用

Steve Pavlov¹, Santosh Kumar Prajapati¹, Dhananjay Yadav¹

¹USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL 33613, USA.

|January 28, 2026

概括

植物化合物通过解决关键的病理途径,为阿尔茨海默病 (AD) 管理提供了一个有希望的多目标方法. 传递系统的进步提高了它们的神经保护和治疗疗效的潜力.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
植物化学植物化学

背景情况:

阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,具有复杂的病理学,包括粉样β (Aβ) 聚合和陶过酸化.
目前的阿尔茨海默病治疗方法提供有限的症状缓解,并且在可访问性和长期疗效方面面临挑战.
在传统医学中使用的植物性化合物因其多目标神经保护潜力而受到越来越多的关注.

研究的目的:

审查阿尔茨海默病 (AD) 治疗的主要植物化学品的机制和转化证据.
探索植物衍生化合物的神经保护机制,以防止AD病理.
评估先进的输送系统在提高AD的植物化学疗效方面的潜力.

主要方法:

对植物化学品的机制和翻译研究进行系统审查.
化合物的分析包括维他诺化物,黄素,银杏化物,宝化物,人参化物,克罗辛/萨夫拉纳尔,表甲基-3-酸盐,罗斯马林酸和亚化物.
对植物化学品新型药物输送平台的临床前数据的评估.

主要成果:

植物化学物质表现出多目标的神经保护作用,包括抑制Aβ聚合,降低陶酸化,抗氧化,抗炎和胆固醇调节.
化合物通过BDNF/CREB通路增强突触可塑性,并调节肠道微生物群.
在临床前模型中,先进的输送系统 (脂质体,纳米粒子) 显示出更好的稳定性,血脑屏障的透,以及治疗疗效.

结论:

植物衍生植物化学物质代表了阿尔茨海默氏症 (AD) 管理的有希望的,负担得起的,多模式候选者.
它们在准相互连接的AD途径方面的协同潜力提供了一个新的治疗策略.
通过先进的传递系统克服生物可用性和新陈代谢挑战对于临床翻译至关重要.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.血脑屏障血脑屏障血脑屏障血脑屏障肠大脑轴肠大脑轴多目标疗法多目标疗法神经炎症是一种神经炎症.神经保护神经保护氧化应激是一种氧化应激.植物化学品植物化学品

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