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Updated: Jan 29, 2026

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells
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工程单链抗体片段 (scFv) 变体向A分解素和金属蛋白酶-17 (ADAM-17) 的变体

Masoud Kalantar1, Elham Khorasani Buxton2, Korey M Reid3

  • 1Department of Chemical and Materials Engineering, University of Nevada, Reno, NV 89557, USA.

Biomolecules
|January 28, 2026
PubMed
概括

研究人员设计了针对ADAM-17的高亲和度单链抗体,ADAM-17是一种参与疾病的金属蛋白酶. 这项工作为开发针对金属蛋白酶的选择性抗体疗法提供了框架.

关键词:
在ADAM-17中,它是ADAM-17.抗体工程是针对抗体的工程.指导进化是指导进化的.工程蛋白酶抑制剂的工程抑制剂金属蛋白酶 (metalloproteinase) 是一种金属蛋白酶.单链变量片段 (scFv) 是指一个单链变量片段.酵母表面显示器显示酵母表面.

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