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Kristóf Filipánits1, Gabriella Nagy1, Dávid Kurszán Jász1

  • 1Department of Rheumatology and Immunology, Medical School, University of Pécs, 7632 Pécs, Hungary.

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在全身性硬化症 (SSc) 中血清C-C动机化学联体18 (seCCL18) 的升高表明更严重的多系统性疾病,并预测长期生存率较差. 这种生物标志物可能有助于识别需要更密切监测和干预的SSc患者.

关键词:
CCL18 CCL18 CCL18 CCL18 CCL18 CCL18 CCL18 CCL18 CCL18疾病活动的疾病活动.间歇性肺病 间歇性肺病多器官参与 多器官参与预后 预后 预后血清生物标志物的血清生物标志物幸存率 幸存率 生存率系统性硬化症 系统性硬化症

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科学领域:

  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学
  • 生物标志物发现发现

背景情况:

  • 血清C-C动机化学因子配体18 (seCCL18) 与间歇性肺病和系统性硬化症 (SSc) 的死亡率有关.
  • 它在非肺部器官参与,疾病活性和SSc的长期结果中的作用仍然被低估.

研究的目的:

  • 调查seCCL18在全身性硬化症 (SSc) 队列中的临床相关性.
  • 评估seCCL18与器官参与,疾病活性和存活率的关联.

主要方法:

  • 酶相关免疫吸收试验 (ELISA) 在151名SSc患者和47名健康对照 (HC) 中测量了seCCL18.
  • 升高的seCCL18被定义为>130 ng/mL.
  • 器官参与,疾病活性 (EUSTAR-AI) 和存活率被纵向评估.

主要成果:

  • 在SSc患者中,seCCL18水平明显高于HC患者 (p < 0.01).
  • 升高的seCCL18与SSc-ILD相关,肺功能减弱 (FVC,DLCO),心肌疾病,腹功能障碍和食道干扰.
  • 较高的seCCL18与肌摩擦擦,活跃疾病和炎症标志物 (CRP,ESR) 的升高有关.
  • 在87个月的随访期间,seCCL18独立预测死亡率升高 (HR 1.789,p = 0.013).

结论:

  • 升高的seCCL18标识了SSc患者的严重多系统参与 (心肺,胃肠道,肌肉骨) 和增加的炎症.
  • seCCL18可以作为一个预后生物标志物,用于超出肺部参与范围的广泛SSc.
  • 需要在前性多中心研究中进行进一步的验证,以确定最终的切线值.