血清CCL18可能反映多器官参与,系统性硬化症的结果不佳
Kristóf Filipánits1, Gabriella Nagy1, Dávid Kurszán Jász1
1Department of Rheumatology and Immunology, Medical School, University of Pécs, 7632 Pécs, Hungary.
Biomolecules
|January 28, 2026
概括
在全身性硬化症 (SSc) 中血清C-C动机化学联体18 (seCCL18) 的升高表明更严重的多系统性疾病,并预测长期生存率较差. 这种生物标志物可能有助于识别需要更密切监测和干预的SSc患者.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 血清C-C动机化学因子配体18 (seCCL18) 与间歇性肺病和系统性硬化症 (SSc) 的死亡率有关.
- 它在非肺部器官参与,疾病活性和SSc的长期结果中的作用仍然被低估.
研究的目的:
- 调查seCCL18在全身性硬化症 (SSc) 队列中的临床相关性.
- 评估seCCL18与器官参与,疾病活性和存活率的关联.
主要方法:
- 酶相关免疫吸收试验 (ELISA) 在151名SSc患者和47名健康对照 (HC) 中测量了seCCL18.
- 升高的seCCL18被定义为>130 ng/mL.
- 器官参与,疾病活性 (EUSTAR-AI) 和存活率被纵向评估.
主要成果:
- 在SSc患者中,seCCL18水平明显高于HC患者 (p < 0.01).
- 升高的seCCL18与SSc-ILD相关,肺功能减弱 (FVC,DLCO),心肌疾病,腹功能障碍和食道干扰.
- 较高的seCCL18与肌摩擦擦,活跃疾病和炎症标志物 (CRP,ESR) 的升高有关.
- 在87个月的随访期间,seCCL18独立预测死亡率升高 (HR 1.789,p = 0.013).
结论:
- 升高的seCCL18标识了SSc患者的严重多系统参与 (心肺,胃肠道,肌肉骨) 和增加的炎症.
- seCCL18可以作为一个预后生物标志物,用于超出肺部参与范围的广泛SSc.
- 需要在前性多中心研究中进行进一步的验证,以确定最终的切线值.
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