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Updated: Jan 29, 2026

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线粒体Ca2+信号在三方突触:一个统一的框架,用于谷氨酸平衡,代谢合,和网络脆弱性

Mariagrazia Mancuso1,2, Federico Mezzalira1,2, Beatrice Vignoli1

  • 1Neuroscience Institute, National Research Council of Italy, 35131 Padua, Italy.

Biomolecules
|January 28, 2026
PubMed
概括

线粒体 (Ca2+) 动态整合了突触活动,新陈代谢和氧化还原平衡. 线粒体-谷氨酸轴中的干扰会导致神经退行性疾病 (如阿尔茨海默氏症) 的突触功能障碍.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.天体细胞神经元通信激发性有毒性 激发性有毒性谷氨酸的恒常性 谷氨酸的恒常性谷氨酸作用的突触突触 (glutamatergic synapse) 是一种具有谷氨酸作用的突触.代谢合的代谢合线粒体Ca2+信号传递线粒体的信号传递方式神经元的过度刺激性突触的脆弱性突触的脆弱性

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