设计和混合PLGA-黄素/碳点纳米颗粒的物理化学表征,以持续释放兰胺:一项概念验证研究
Christina Samiotaki1, Stavroula Nanaki1, Rizos Evangelos Bikiaris2
1Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
这项研究开发了一种新的混合纳米粒子系统,用于鼻内胺 (GAL) 输送. 该系统显示出有前途的多相持续释放,增强了潜在治疗应用的GAL生物可用性.
科学领域:
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 阿尔茨海默病的治疗通常涉及胺 (GAL),但其生物利用性有限.
- 鼻内药物输送提供了一种潜在的途径,可以绕过第一通代谢并改善大脑向.
- 开发有效的纳米粒子载体对于成功的鼻内药物递送至关重要.
研究的目的:
- 设计和描述一种混合纳米粒子系统,用于鼻内输送氨酸 (GAL).
- 为了增强 GAL 溶解,稳定性,并实现持续释放.
- 为了研究一个聚乳酸-co-甘油酸) -curcumin (PLGA-Cur) 结合体在调节释放动力学中的作用.
主要方法:
- 混合纳米粒子是使用加载了GAL并纳入PLGA-Cur矩阵的碳点 (CD) 制造的.
- 物理化学表征涉及H-NMR,FTIR光谱和粉末X射线衍射 (pXRD).
- 进行了体外释放研究,以评估随着时间的推移释放特征.
主要成果:
- 证实了PLGA-Cur结合体的成功形成和GAL加载到CD中.
- 装有 GAL 的纳米粒子表现出球形形态,尺寸从 153.7 nm 到 256.3 nm.
- 实验室研究表明,多相持续释放的GAL长达12天.
结论:
- 开发的混合纳米粒子系统显示了对控制的,多相持续的鼻内输送胺的潜力.
- 库尔库明结合有效调节聚合物结构,并影响药物释放动力学.
- 这项概念验证研究为未来对鼻内GAL输送系统的体内评估提供了基础.
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