定期运动对神经和非神经群体外围大脑衍生的神经缩因子的影响:用元回归进行元分析
Mesut Süleymanoğulları1, Aslıhan Tekin1, Halil İbrahim Ceylan2
1Department of Physical Education and Sports Teaching, Faculty of Sport Sciences, Agri Ibrahim Cecen University, Agri 04100, Turkey.
Brain sciences
|January 28, 2026
概括
在各种神经和非神经疾病中,运动显著提高脑衍生神经营养因子 (BDNF) 水平. 耐力和有氧运动显示出最好的改善,强调运动.
科学领域:
- 神经科学和运动生理学
- 神经可塑性的生物标志物
- 临床研究和元分析
背景情况:
- 大脑衍生神经营养因子 (BDNF) 对神经可塑性,认知和心理健康至关重要.
- 运动是一种潜在的非药物方法来增加BDNF,但在疾病中发现的结果是不一致的.
- 运动类型和剂量对BDNF水平的影响需要澄清.
研究的目的:
- 在神经和非神经疾病中对运动干预对外围BDNF水平的影响进行元分析.
- 调查结果是否因疾病类别,运动方式或剂量而有所不同.
- 评估运动参数的影响,如持续时间,频率和会话长度.
主要方法:
- 在主要数据库中进行系统的文献搜索,直到2025年10月.
- 包括19个随机对照试验 (RCT) 与850名参与者.
- 使用随机效应模型,子组分析,元回归和出版偏差测试的分析.
主要成果:
- 运动显著增加了外围BDNF水平 (SMD=1.03) 的低质量证据.
- 在神经和非神经条件中都观察到改善.
- 耐力 (SMD = 1.57) 和有氧 (SMD = 1.44) 运动比联合运动 (SMD = 0.55) 有更大的效果;剂量参数没有显著调节结果,除了年龄和基线BDNF.
结论:
- 运动干预措施在各种临床人群中有效地增加了外围BDNF.
- 抵抗和有氧运动方案特别有效,但与剂量相关的因素不能解释这种变化.
- 尽管目前的证据有限,但需要进一步高质量的,预先注册的RCT和标准化的协议来确认研究结果并指导临床翻译.
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