针对中枢神经系统炎症性脱线性疾病的生活方式:从饮食和运动作为潜在的疾病修饰剂的见解
Eleonora Virgilio1,2, Federico Abate Daga1, Matteo Bronzini2
1Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.
饮食和运动可以改变中枢神经系统的炎症性疾病,如多发性硬化症 (MS). 生活方式干预有望减少复发并促进神经保护,特别是当与治疗相结合时.
科学领域:
- 神经免疫学 神经免疫学
- 生活方式 医学 医疗
- 神经学 神经学
背景情况:
- 中枢神经系统的炎症性疾病,包括多发性硬化症 (MS),神经omyelitis光学谱障碍 (NMOSD) 和MOG抗体相关疾病 (MOGAD),受到各种因素的影响.
- 饮食和体育活动越来越多地被认为是它们在疾病调节中的潜在作用.
研究的目的:
- 审查饮食和体育炼作为MS,NMOSD和MOGAD中潜在的辅助疾病修饰剂的影响.
- 探索生活方式干预的神经保护和抗炎作用.
主要方法:
- 临床前和临床研究的叙述性综述.
- 分析多发性硬化症 (MS) 研究的证据,考虑NMOSD和MOGAD的临床前数据.
主要成果:
- 健康饮食 (地中海,MIND) 和运动与较轻微的MS过程,减少复发和保持大脑体积相关.
- 性饮食,间歇性热量限制,有氧运动和抵抗训练显示出神经保护性益处,并可能改善功能/认知结果.
- 生活方式干预可能与MS的疾病修饰治疗 (DMT) 协同作用.
结论:
- 饮食和运动是管理中枢神经系统炎症疾病的有希望的辅助策略,特别是MS.
- 个性化的生活方式干预应在疾病管理的早期阶段被整合起来.
- 需要进一步的大规模标准化试验来证实对NMOSD,MOGAD和更广泛的中枢神经系统疾病的益处.
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