纤维肌痛认知功能障碍:患病率和独立预测因素-使用蒙特利尔认知评估尺度的病例对照研究.
Sofia Ferreira Azevedo1,2, Inês Genrinho3, Joana Saldanha4
1Rheumatology Department, Unidade Local de Saúde da Região de Aveiro, Av. Artur Ravara, 3800-164 Aveiro, Portugal.
Brain sciences
|January 28, 2026
概括
认知功能障碍影响超过70%的纤维肌痛患者,显著影响他们的生活质量. 疼痛,抑郁和疾病严重程度是纤维肌痛中这种认知障碍的关键独立预测因素.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 类风湿病学 类风湿病学
背景情况:
- 认知功能障碍是纤维肌痛 (FM) 中常见但未被认可的症状.
- 患病率估计和FM认知障碍的独立临床预测因素仍然不清楚.
- 这项研究调查了与对照组相比,在FM患者中认知功能障碍的患病率,并确定了相关因素.
研究的目的:
- 为了确定纤维肌痛患者认知功能障碍的患病率.
- 确定与纤维肌痛认知功能障碍相关的独立临床预测因素.
- 为了比较纤维肌痛患者和健康对照者的认知功能.
主要方法:
- 一项病例控制研究与47名成年女性纤维肌痛患者和19名年龄和性别匹配的健康对照进行.
- 使用蒙特利尔认知评估 (MoCA) 评估认知功能,以MoCA<26定义的功能障碍.
- 疼痛,疲劳,焦虑,抑郁,睡眠质量和疾病影响使用经过验证的尺度来评估.
主要成果:
- 认知功能障碍在纤维肌痛患者 (72.3%) 与对照组 (5.3%) (p < 0.001) 相比非常普遍.
- 纤维肌痛患者报告说,疼痛,疲劳,心理困扰,睡眠质量和生活质量明显恶化.
- 在FM患者中,更高的疾病影响 (FIQ-P),疼痛严重程度和抑郁症独立与认知功能障碍和较低的MoCA得分有关.
结论:
- 认知功能障碍是纤维肌痛的一个非常普遍的特征.
- 疼痛严重程度,抑郁症状和疾病影响是与纤维肌痛认知功能障碍相关的独立因素.
- 针对疼痛,抑郁和疾病的影响可能有助于改善纤维肌痛患者的认知功能.
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