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Updated: Jan 29, 2026

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轻度创伤性脑损伤后的严重程度和恢复的性别差异:系统性审查
Shanika Arachchi1, Ed Daly1, Anushree Dwivedi2
1Department of Sport, Exercise and Nutrition, Atlantic Technological University, H91 T8NW Galway, Ireland.
Brain sciences
|January 28, 2026
概括
女性在轻度创伤性脑损伤 (mTBI) 后经历更严重的症状和更慢的恢复. 了解这些基于性别的差异对于开发针对性诊断和康复策略对于mTBI患者至关重要.
科学领域:
- 神经科学是一个神经科学.
- 创伤学 创伤学 创伤学
- 公共卫生 公共卫生
背景情况:
- 基于性别的生物和神经化学变异会影响轻度创伤性脑损伤 (mTBI) 的呈现和恢复.
- 调查mTBI的性别相关差异对于了解患者的不同结果至关重要.
- 之前的研究表明mTBI中存在潜在的性别差异,需要进行全面的审查.
研究的目的:
- 系统地审查和综合现有关于轻度创伤性脑损伤 (mTBI) 严重程度,症状和恢复的基于性别的差异的文献.
- 确定男性和女性经历和从mTBI中恢复的具体模式.
- 在mTBI管理中提供性别特定的诊断和康复方法的证据.
主要方法:
- 按照PRISMA 2020指南进行系统审查,并注册在PROSPERO.
- 在PubMed,SPORTDiscus,科学网络和Scopus (2000-2024) 中进行全面的文献搜索.
- 包括成人研究 (≥18岁) 的mTBI/脑震荡和可量化的性别特异性结果数据;用于质量评估的JBI批判性评估工具.
主要成果:
- 41项研究 (15,656名参与者) 显示,女性报告了更大的症状负担,疼痛和更长的恢复时间.
- 神经成像显示女性白质变化更多,男性脑血流减少.
- 与男性相比,女性的认知表现较差,反应时间较慢,前体眼和视觉异常的发生率较高.
结论:
- 性别显著影响mTBI症状表现和恢复轨迹.
- 在mTBI后的多个临床领域中,女性似乎更容易受到伤害,可能是由于生物学因素.
- 识别性别特异性模式对于定制mTBI诊断和康复策略以改善患者结果至关重要.
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