卡尔帕因-2 调节神经毒素诱导的运动神经元损伤中的素和素功能障碍

Vandana Zaman1,2, Camille Green1,2, Kayce Sitgreaves1,3,4

  • 1Ralph H. Johnson Veterans Administration Medical Center, 109 Bee Street, Charleston, SC 29401, USA.

Brain sciences
|January 28, 2026
PubMed
概括

在帕金森病 (PD) 模型中,calpain-2的激活会通过破坏运动蛋白质kinesin和dynein来破坏细胞内运输. 抑制calpain-2可以恢复运输功能,并可能提供新的PD治疗策略.

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