创伤后嗅觉功能障碍的前额神经调节路线:在左DLPFC rTMS期间的恢复支持的观点
Chiara Di Fazio1,2, Sara Palermo1,3,4
1Department of Psychology, University of Turin, 10124 Turin, Italy.
Brain sciences
|January 28, 2026
概括
在左脊侧前额叶皮层 (DLPFC) 上进行高频重复性横磁刺激 (rTMS) 显示出在轻度创伤性脑损伤 (mTBI) 后治疗创伤后嗅觉功能障碍的前景. 一个单一的案例研究报告了在rTMS治疗后显著的嗅觉恢复.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 创伤后嗅觉功能障碍 (PTOD) 是轻度创伤性脑损伤 (mTBI) 的常见和持久的后果.
- 目前基于证据的PTOD治疗选择有限.
- 神经调节干预正在探索神经恢复.
研究的目的:
- 为了研究高频重复性跨脑磁性刺激 (rTMS) 应用到左背侧前额叶皮层 (DLPFC) 的潜力,用于治疗PTOD.
- 探索机械路径,包括嗅觉,注意力和奖励网络的自上向下调制,通过rTMS可能促进嗅觉恢复.
- 概述这一领域未来研究的关键机制和方法考虑.
主要方法:
- 一个70岁的妇女的病例研究,患有严重的创伤后缺血症,持续约5个月.
- 治疗涉及12周的10HzrTMS在左侧DLPFC上,包括36次每次800脉冲的36次会议.
- 嗅觉功能使用结构化日记和在不同的气味类别中重复评分来评估.
主要成果:
- 患者报告说,嗅觉功能逐步改善,从10至12个疗程开始,尖的气味重新出现.
- 到12周治疗结束时,观察到广泛的嗅觉恢复,包括感知微妙香味的能力.
- 在rTMS治疗过程中没有报告任何不良事件.
结论:
- 这一案例表明,高频rTMS在左侧DLPFC上可能是创伤后嗅觉功能障碍的可行治疗方法.
- 观察到的嗅觉恢复模式与网络级神经调节效应一致.
- 将标准化嗅觉测试与神经生理学和神经成像技术相结合的受控试验是有必要的,以确定因果关系并进一步阐明机制.
关键词:
脊侧前额叶皮层 (DLPFC) 是一个前额叶皮层.缺血症 缺血症是一种缺血症.轻度创伤性脑损伤 (mTBI) 是一种轻度创伤性脑损伤.通过神经调节进行神经调节.嗅觉 嗅觉是一种嗅觉.在创伤后的嗅觉功能障碍.重复性横性磁性刺激 (rTMS) 的方法更多相关视频
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