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在正义牙牙移动过程中表达血管内皮生长因子的衰老细胞的力量依赖存在
Yohei Morihana1, Masato Nakagawa2, Yue Zhou3
1Department of Orthodontics, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata 573-1121, Osaka, Japan.
Biology
|January 28, 2026
概括
最佳的正牙力大小通过影响血管生长和衰老细胞来影响牙运动. 较低的力量促进血管生成和血管内皮生长因子 (VEGF) 表达,而较高的力量抑制这些过程.
科学领域:
- 生物医学工程 生物医学工程
- 矯正牙科 矯正牙科是一種矯正牙科.
- 细胞生物学 细胞生物学
背景情况:
- ортодонтика力大小对于 ортодонтика牙运动 (OTM) 是至关重要的.
- 老化细胞在OTM相关血管生成中的作用尚不清楚.
- 血管内皮生长因子 (VEGF) 在血管生成中起着关键作用.
研究的目的:
- 为了研究OTM期间老化的细胞的局部化和VEGF表达,使用不同的力大小.
- 为了确定不同 ортодонтических 强力水平对血管生成在老鼠模型的影响.
主要方法:
- 通过使用60g或180g的正牙力建立了一种大鼠水平OTM模型.
- 使用立体显微镜和微型计算机断层扫描来评估牙的运动.
- 衰老标志物 (p21,p16) 和血管生成标志物 (CD31,VEGF) 通过多重免疫光检测进行了评估.
主要成果:
- 60g力组表现出增加的细胞性,血管密度和VEGF表达,表明最佳力.
- 180g力组显示细胞性和血管生成减少,这表明过度的力.
- 衰老细胞在60g组中更为普遍,超过40%表达VEGF.
结论:
- ортодонтика力的大小显著影响在OTM期间表达VEGF的衰老细胞的存在.
- 阳性VEGF衰老细胞可能在正义牙移动期间在血管生成过程中发挥作用.
- 研究结果提供了对牙矯正中最佳力应用机制的见解.
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