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麻症预测了新辅助化疗的膀癌死亡率:一个多中心研究
Alice Pitout1, Charles Mazeaud1,2, Alicia Blondeau1
1Department of Urology, CHRU de Nancy, 54500 Vandoeuvre -lès-Nancy, France.
Cancers
|January 28, 2026
概括
肌肉质量的衡量标准 - - 肉是接受新辅助化疗的膀癌患者死亡率的重要预测因子. 这项研究强调了其预后价值,并比较了不同的测量值,以改善临床评估.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 老年病的医生 老年病的医生
背景情况:
- 通过CT扫描评估的肉类是众所周知的各种癌症的负面预后因素.
- 它在接受新辅助化疗的膀癌患者中的作用尚未确立.
- 这项研究调查了sarcopenia对这种特定患者群体的生存结果的预后影响.
研究的目的:
- 为了评估萨科佩尼亚对膀癌患者生存的预后意义.
- 为了比较不同的sarcopenia测量值及其对预后准确性的影响.
- 评估萨科佩尼亚与无进展生存 (PFS) 和病理完整反应 (pCR) 的关联.
主要方法:
- 74名侵袭性尿路细胞癌患者接受新辅助化疗和囊切除术 (2015-2021) 的回顾性多中心研究.
- 在化疗前 (BC) 和手术前 (BS) 的CT扫描上使用骨肌肉指数评估的肉症.
- 主要终点:整体存活率. 二次终点:PFS,pCR,治疗并发症.
主要成果:
- 麻症的患病率为27%的BC和39%的BS.
- 萨科佩尼亚与所有原因死亡率的增加 (HR 3.38-6.08,p=0.012-0.032) 和PFS的缩短显著相关.
- 40%的人实现了pCR,35%的人出现了复发;PFS的中位数是25个月.
结论:
- 麻症是膀癌患者死亡率的独立和可重现的预后因素.
- 这项研究首次比较了不同时间点 (BC与BS) 的肉症值.
- 调查结果表明,将肉症评估纳入临床实践,以进行风险分层.
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