瘤微环境:胰腺管道腺癌中的多参数MRI的洞察力
Ramesh Paudyal1, James Russell1, H Carl Lekaye1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Cancers
|January 28, 2026
概括
多参数MRI定量成像生物标志物 (QIBs) 显示胰腺管腺癌 (PDAC) 瘤微环境的早期治疗变化. 这些QIB与瘤细胞含量相关,为PDAC治疗中的共临床研究提供了潜力.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 胰腺管道腺癌 (PDAC) 具有密集的肌层,阻碍治疗疗效.
- 了解瘤微环境 (TME) 中早期治疗诱导的变化对于改善PDAC结果至关重要.
研究的目的:
- 通过使用多参数MRI (mpMRI) 衍生的定量成像生物标志物 (QIBs) 调查PDAC TME在治疗后早期的变化.
- 在临床前PDAC模型中将mpMRI-QIB与组织学发现相关联.
- 评估使用标准的mpMRI协议在PDAC患者中获得这些QIB的可行性.
主要方法:
- mpMRI,包括扩散权重 (DW) 和动态对比增强 (DCE) 序列,在临床前PDAC模型和PDAC患者中进行.
- 分别使用单指数和扩展Tofts模型分析了DW和DCE数据.
- 在H&E染色组织中,DeepLIIF量化了瘤细胞百分比;用于分析的是斯皮尔曼相关性和威尔科克森签名等级测试.
主要成果:
- 在临床前模型中观察到明显扩散系数 (ADC) 和Ktrans值的治疗前和治疗后显著差异.
- 治疗后的ADC和细胞外体积的相对变化 (rΔve) 与瘤细胞百分比负相关.
- 在PDAC患者的治疗前平均ADC和Ktrans值分别为1.76 × 10−3 mm2/s和0.24 min−1.
结论:
- mpMRI衍生的QIB显示出在PDAC TME中监测早期治疗反应的潜力.
- 这些QIB显示出对共临床研究的前景,评估针对PDAC中的瘤和筋膜的新型治疗策略.
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