基于MRI的三角形缩作为在软组织肉瘤中接受新辅助化疗后的预后标记
Harold Bravo Thompson1, Priya Chattopadhyay1, Ty Subhawong2
1Department of Medicine, University of Miami/Jackson Health System, Miami, Fl 33136, USA.
Cancers
|January 28, 2026
概括
在化疗后的MRI上软组织瘤缩的变化不能预测治疗反应或患者的生存. 放射性亡的评估需要通过先进的成像和分子工具进一步细化.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 病理学 病理学 病理学
背景情况:
- 在软组织肉瘤 (STS) 中治疗诱导的亡的预后意义尚未得到充分确立.
- 在STS中评估治疗反应通常依赖于成像,但死变化的可靠性是不确定的.
研究的目的:
- 调查基于MRI的亡变化 (Δ亡) 和STS患者在新辅助化疗后的病态亡之间的相关性.
- 为了确定MRI衍生的亡是否预测临床结果,包括无进展和整体存活率.
主要方法:
- 对27名接受新辅助化疗和接受治疗前后MRI的STS患者进行了回顾性分析.
- 在MRI上对亡的分类分级和 Δ 亡的计算;使用斯皮尔曼等级系数与病态亡的相关性.
- 使用卡普兰-梅尔和日志等级测试的生存分析 (无进展,无局部复发,特定疾病的总生存率).
主要成果:
- 治疗后的MRI缩与病理性缩有中度的相关性 (ρ = 0.44,p = 0.028).
- Δ亡与病态亡的相关性较弱,不显著 (ρ = 0.24,p = 0.24).
- 无论是基于MRI的,还是病理性亡值都与患者生存结果没有显著的关联.
结论:
- 基于MRI的Δ缩并不是STS病理性缩或瘤结局的可靠预测指标.
- 亡中的放射性变化可能不准确地反映STS的治疗反应.
- 未来的研究应该整合定量成像,标准化病理学和分子工具,如ctDNA,以改善治疗评估.
相关概念视频
01:16Necrosis
6.5K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.5K
01:17The Delta-to-Delta Circuit
1.1K
In a delta-delta configuration, the source and the load are connected in a delta manner, forming a closed loop that divides the network into three distinct phases. This configuration makes the phase voltages identical to line voltages. Assuming the sources are in positive sequence, the phase voltages can be expressed directly without having a neutral wire.
1.1K
01:19The Y-to-Delta Circuit
706
A balanced wye-to-delta circuit comprises balanced Y-connected voltage sources and delta-connected loads with no neutral line connection.
The initial step in analyzing a wye-to-delta circuit is to assume a positive phase sequence. These phase voltages are then utilized to calculate the line voltages that occur directly across the delta-connected load impedances. Van, Vbn, and Vcn are the phase voltages in wye, and Vab, Vbc, and Vca are the line voltages for a delta circuit. The relation between...
The initial step in analyzing a wye-to-delta circuit is to assume a positive phase sequence. These phase voltages are then utilized to calculate the line voltages that occur directly across the delta-connected load impedances. Van, Vbn, and Vcn are the phase voltages in wye, and Vab, Vbc, and Vca are the line voltages for a delta circuit. The relation between...
706
01:16The Delta-to-Y Circuit
860
In the delta-wye circuit, the source is delta-connected, while the load is in a wye configuration. This means that the phase voltage of the delta-connected source is equal to the line voltage of the wye-connected load. The connection between two-line currents originates from the delta-connected source. The phase difference in the balanced system allows for calculating one line current given the other, utilizing the positive sequence of phases. In the delta-wye system, the phase currents in the...
860
01:03Rous Sarcoma Virus (RSV) and Cancer
6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.4K
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
779
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
779