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揭露女性因素:膀癌激进囊切除术后的结果和生存率的性别差异
Federico Ceria1, Gad Muhammad1, Francesco Del Giudice2,3
1Guy's and St. Thomas' NHS Foundation Trust, Guy's Hospital, London SE1 7EH, UK.
Cancers
|January 28, 2026
概括
性别不会影响大批量中心的激进囊切除结果. 膀癌的标准化护理可能会减少经过囊切除术的男性和女性之间的历史生存差异.
科学领域:
- 尿瘤学 尿瘤学
- 手术瘤学手术瘤学
- 医学中的性别差异.
背景情况:
- 从历史上看,经过激进囊切除术 (RC) 的膀癌女性患者的生存率低于男性,通常是由于疾病晚期.
- 导致这些差异的因素包括生物差异,延迟诊断和多样化的治疗.
- 新出现的证据表明,在大量的多学科中心,结果可能会相等.
研究的目的:
- 评估性别对手术前期结果和激进囊切除术后瘤结果的影响.
- 为了比较男性和女性患者之间的无疾病生存率 (DFS),疾病特异性生存率 (DSS) 和整体生存率 (OS).
主要方法:
- 预期维护的数据库的回顾性分析,其中包括887名因尿路癌而接受激进囊切除术 (RC) 的患者 (2014-2023年).
- 人口统计学,外科外科和病理学变量按性别分层.
- 卡普兰-梅尔分析被用来评估与性别相关的DFS,DSS和OS.
主要成果:
- 性别之间平均年龄或瘤组织学没有显著差异.
- 可比较的病理阶段分布和从转诊到手术的时间.
- 在12个月的DFS (77.3%对75.4%),DSS (85.6%对86.9%) 或OS (81.2%对85.2%) 中没有明显的性别相关差异.
结论:
- 在一个大量的三级中心,性别并没有独立地影响激进囊切除术后的外科手术或生存结果.
- 在专门的膀癌途径中进行标准化,多学科的管理可能有助于克服与性别有关的历史差异.
- 这些发现支持复杂的泌尿瘤手术的集中护理.
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