乳头甲状腺癌的侵略性变体的临床行为:一个回顾性病例对照研究
Jovan Ilic1, Nikola Slijepcevic1,2, Katarina Tausanovic1,2
1Clinic for Endocrine Surgery, University Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia.
Cancers
|January 28, 2026
概括
罕见的乳头甲状腺癌 (PTC) 变体被归类为高风险,表现出侵略性行为和较差的生存率. 低风险变体具有良好的生存率,但涉及特征,而中等风险变体与经典PTC相似.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 乳头甲状腺癌 (PTC) 是最常见的内分泌恶性瘤.
- 经典的PTC (cPTC) 通常有一个惰的过程.
- 罕见的PTC亚型经常表现为具有侵略性的临床行为.
研究的目的:
- 为了评估罕见的PTC变体的攻击性.
- 将罕见PTC变异的临床病理特征 (CPC) 和生存结果与cPTC进行比较.
主要方法:
- 对80名患有罕见PTC变体的患者的分析 (2009-2019).
- 变种分为高风险 (HRV),中等风险 (IRV) 和低风险 (LRV) 的分类.
- 将CPC和生存结果 (OS,DSS,DFS) 与匹配的cPTC对照进行比较.
主要成果:
- 与cPTC相比,HRV表现出明显更具攻击性的CPC和更差的生存结果 (OS,DSS,DFS) (p < 0.001).
- 与cPTC相比,IRV (固体变异) 在CPC或生存率上没有显著差异.
- LRVs (瘤细胞,Warthin-like) 的生存率很好,但与不利的CPCs相关.
- 多变量分析确定HRV分类是复发的唯一独立预测因素 (p = 0.014).
结论:
- 高风险变种 (高细胞,扩散性硬化,柱状细胞, hobnail) 证实了它们的攻击性和更差的预后.
- 固体变体不表现出攻击性特征,与此前的假设相反.
- 细胞和状变体,虽然具有与cPTC相似的生存率,但由于潜在的不良CPCs,需要谨慎.
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