在高风险人群中引起口腔 кандидоз的Candida物种的分布:系统性审查
João Pedro Carvalho1, Jéssica Rodrigues1, Célia Fortuna Rodrigues2,3,4,5
1UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Science (IUCS), 4585-116 Gandra, Portugal.
Healthcare (Basel, Switzerland)
|January 28, 2026
概括
香虫 (Candida albicans) 是口腔香病的最常见原因,但非香虫 (Candida) 种类正在增加. 抗真菌耐药性的增加需要针对这些具有挑战性的真菌感染制定新的治疗策略.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在过去的十年中,由Candida物种引起的感染,特别是口腔候群病,显著增加.
- 虽然Candida albicans仍然是占主导地位的物种,但已经观察到归因于非白类Candida (NAC) 物种的感染率上升.
- 免疫功能受损的个体越来越多的人口有助于Candida感染的流行率增加.
研究的目的:
- 为了确定最常涉及口腔角膜炎的特定的Candida物种.
- 为了分析Candida albicans与非白虫Candida物种在口腔感染中的流行率.
- 提供对口腔疹病原体不断变化的景观的见解.
主要方法:
- 在PubMed,Cochrane图书馆和ScienceDirect数据库中进行了系统的文献搜索.
- 包括2013年至2025年10月期间发表的研究,使用关键词:"candida spp"",口腔角膜炎"和"口腔分离物".
- 根据PRISMA指南,分析了24项符合条件的研究数据,包括12750个Candida分离物.
主要成果:
- 最常见的物种是Candida albicans,占所有口腔分离物的81.7%.
- 非白的Candida (NAC) 种类较少,其中Candida tropicalis (7.2%),Candida glabrata (4.5%) 和Candida krusei (4.1%) 是最常见的.
- 其他被确定的NAC物种包括C. parapsilosis,C. dubliniensis,C. kefyr,C. guilliermondii和C. lusitaniae,所有这些都有较低的频率.
结论:
- 香菌 (Candida albicans) 仍然是口腔香病的主要原因,但NAC物种的发病率正在逐渐上升.
- 在Candida物种中增加抗真菌耐药性对治疗疗效构成重大挑战.
- 耐药菌株的出现和Candida物种之间的潜在相互作用凸显了迫切需要新的治疗方法.
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