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运动耐久性与间歇性关中的再血管化:对随机试验的更新元分析,重点关注以患者为中心的结果

Mislav Puljevic^1,2, Petra Grubic-Rotkvic², Mia Dubravcic-Dosen²

¹School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.

Healthcare (Basel, Switzerland)

|January 28, 2026

概括

监督运动疗法 (SET) 是由于持续改善生活质量而导致间歇性喉 (IC) 的首选一线治疗方法. 内血管再血管 (ER) 提供更快的缓解,但具有长期限制.

科学领域:

血管外科血管外科
干预心脏病学干预心脏病学
康复医学康复医学康复医学

背景情况:

间歇性音 (IC) 是下肢外周动脉疾病 (PAD) 的常见症状.
监督运动疗法 (SET) 和内血管再血管化 (ER) 是已建立的IC治疗方法.
对SET,ER和联合ER+SET对与健康相关的生活质量 (HRQoL) 的比较长期影响需要进一步澄清.

研究的目的:

对IC进行SET,ER和ER+SET比较的随机对照试验 (RCT) 进行系统审查和元分析.
在不同时间点评估与健康相关的生活质量 (HRQoL) 的首要结果.
为了比较对步行距离和不良事件的影响.

主要方法:

在PubMed,Embase和CENTRAL发表的RCT的系统审查和元分析,直到2024年12月.
纳入标准:IC患者 (不包括关键四肢缺血症) 的RCT报告了经过验证的HRQoL结果在≥3个月.
数据提取和偏差风险评估 (Cochrane RoB 2.0) 由两个独立审稿人进行;使用随机效应的元分析.

主要成果:

包括五个RCT (n=728) 在内. 与最佳医疗治疗相比,SET和ER都改善了HRQoL和步行距离.
在12个月后,在SET和ER之间没有发现HRQoL的显著差异 (SMD 0.02).
ER+SET优于单独使用的SET (SMD 0.35). 在24个月以后,SET显示了持续的HRQoL改善,而ER的好处随着更高的再干预率 (20-30%在2年内) 而减弱.

结论:

SET 应该仍然是间歇性音的第一线疗法,提供持久的HRQoL益处,最小的伤害.
紧急救治能更快地缓解症状,但受到缩和重复手术的限制,特别是在股骨关节疾病中.
中等确定性证据支持SET作为首选的初始治疗方法,以改善IC中的以患者为中心的结果.

关键词:

在 PAD PAD 里面,你会看到一些东西.关键词: 关键词关键词关键词运动就是炼身体.

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