不受管制的药物滥用和系统性炎症标记:一项审查
Carmen Lara-Apolinario1,2, Jose Barroso1,3, Jose Carlos Rodríguez-Gallego1
1Medicine Department, Fernando Pessoa Canarias University, 35450 Guía, Spain.
Healthcare (Basel, Switzerland)
|January 28, 2026
概括
系统性炎症标志物,特别是中性粒细胞-淋巴细胞比率 (NLR),与药物滥用障碍有关. 在甲基胺和阿片类药物使用者中观察到较高的NLR值,这表明成的潜在生物标志物.
科学领域:
- 医学研究 医学研究
- 临床毒理学 临床毒理学
- 炎症和免疫学 炎症和免疫学
背景情况:
- 药物成是一种复杂的疾病,具有重大公共卫生影响.
- 系统性炎症在成病理生理学中的作用需要进一步阐明.
- 中性粒细胞-淋巴细胞比率 (NLR) 是一个新兴的炎症生物标志物.
研究的目的:
- 系统地审查和综合有关无管制物质成和系统性炎症参数之间的联系的证据.
- 评估中性粒细胞-淋巴细胞比率 (NLR) 作为药物滥用障碍的潜在生物标志物.
主要方法:
- 按照PRISMA 2020指南进行系统审查,在PROSPERO.中注册.
- 搜索了PubMed和Scopus数据库 (2025年7月) 关于物质使用和炎症生物标志物的研究 (2015-2025年).
- 包括15项研究,通过STROBE检查清单评估方法质量.
主要成果:
- 在甲基胺和阿片类药物使用者中观察到高的NLR和单细胞与淋巴细胞比率 (MLR).
- 在可卡因滥用中报告的NLR增加,尽管证据有限.
- 关于大麻使用与NLR之间的关联的不一致的发现.
结论:
- 系统性炎症标志物与药物滥用障碍有关.
- 目前的证据基础有限,这突显了对强大,有前景的临床试验的需求.
- 作为一个成的生物标志物,NLR显示出潜在的潜力,需要进一步调查.
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