心血管-脏-代谢综合征中的体力活动和双向阶段过渡:一个队列研究
Chuan Mou1, Xinrui Miao2, Zhihua Wang1
1Institute of Physical Education, Sichuan University, Chengdu 610065, China.
Healthcare (Basel, Switzerland)
|January 28, 2026
概括
参与中度至高水平的体力活动显著降低了通过心血管--代谢 (CKM) 综合征阶段进展的风险. 更高的活动水平也促进了CKM阶段之间的改进,有助于预防和管理.
科学领域:
- 心血管健康的心血管健康
- 功能 功能 功能
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 公共卫生
背景情况:
- 心血管-脏-代谢 (CKM) 综合征包括相互关联的心血管,脏和代谢条件.
- 身体活动和CKM阶段过渡之间的确切剂量反应关系尚未得到充分确立.
研究的目的:
- 调查身体活动水平与心血管--代谢 (CKM) 综合征阶段进展和改善的风险之间的关联.
- 探索身体活动和双向CKM阶段过渡之间的剂量反应关系.
主要方法:
- 利用来自中国健康与退休长度研究 (CHARLS) 的数据,对10,868名参与者进行了14,310次观察.
- 采用连续时间的多态马尔科夫模型,用于纵向分析,采用5态结构 (n = 3442).
- 根据MET-min/week,将体育活动分类为四分位数 (Q1-Q4),并分析了低风险 (阶段 0-2) 和高风险 (阶段 3-4) 状态之间的过渡.
主要成果:
- 较高的体力活动四分位数 (Q2-Q4) 与高风险CKM阶段的风险显著降低 (43.1%53.1%的降低与Q1相比).
- 限制立方脊线 (RCS) 分析显示,身体活动和CKM阶段进展之间存在非线性剂量反应关系.
- 在最高四分位数 (Q4) 的身体活动减少了过渡到高风险状态 (HR=0.598),并促进了过渡到低风险状态 (HR=2.995).
结论:
- 中等到高水平的体力活动有效地降低了心血管--代谢 (CKM) 综合征进展的风险.
- 身体活动促进了CKM阶段之间的改善,为CKM预防和管理提供了可行的策略.
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