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相关概念视频

Quantifying Heat02:46

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Thermal Energy Microscopically, thermal energy is the kinetic energy associated with the random motion of atoms and molecules. Temperature is a quantitative measure of “hot” or “cold”, which depends on the amount of thermal energy. When the atoms and molecules in an object are moving or vibrating quickly, they have a higher average kinetic energy (KE) (or higher thermal energy), and the object is perceived as “hot”, or it is described as being at a higher temperature. When the...
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Heating and Cooling Curves02:44

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When a substance—isolated from its environment—is subjected to heat changes, corresponding changes in temperature and phase of the substance is observed; this is graphically represented by heating and cooling curves.
For instance, the addition of heat raises the temperature of a solid; the amount of heat absorbed depends on the heat capacity of the solid (q = mcsolidΔT). According to thermochemistry, the relation between the amount of heat absorbed or released by a substance, q, and its...
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Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
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Specific Heat01:16

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The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Heat is a type of energy transfer that is caused by a temperature difference, and it can change the temperature of an object. Since heat is a form of energy, its SI unit is the joule (J). Another common unit of energy often used for heat is the calorie (cal), which is defined as the energy needed to change the temperature of 1 g of water by 1 °C, specifically between 14.5 °C and 15.5 °C, since the energy needed shows a slight temperature dependence. Another commonly used unit is...
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相关实验视频

Updated: Jan 29, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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胚胎热操纵影响神经发育,并诱导层中的耐热性.

Zixuan Fan1,2, Yuchen Jie1,2, Bowen Niu1,2

  • 1Frontier Science Center for Molecular Design Breeding, State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing 100193, China.

Genes
|January 28, 2026
PubMed
概括

胚胎热操纵 (ETM) 可以提高家禽的耐热性,但会对化能力和大脑发育产生负面影响. 这项研究揭示了ETM.

关键词:
胚胎热处理的热操纵耐热性 耐热性 耐热性层层层层层层层层层层层层层.分子监管网络分子监管网络神经发育的神经发育

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科学领域:

  • 动物科学动物科学
  • 发展生物学 发展生物学
  • 基因组学就是基因组学.

背景情况:

  • 禽业面临着严重的热应激挑战,影响动物福利和经济可持续性.
  • 胚胎热操纵 (ETM) 是一项提议的策略,以提高小的耐热性,但其对层的影响需要进一步研究.
  • 对于ETM对生长表现和神经发育的影响在很大程度上仍未被描述.

研究的目的:

  • 为了验证ETM在增强层的耐热性方面的有效性.
  • 研究ETM对化性能,生长和神经发育的影响.
  • 阐明ETM对大脑和下丘脑的影响背后的分子机制.

主要方法:

  • 在13-18个胚胎日期间,白色雷戈恩胚胎在39.5°C的温度下接受ETM.
  • 评估了大脑部分的特征特征,耐热性,形态测量和组织病理学.
  • 整个大脑和下丘脑转录基因分析确定了差异表达基因 (DEGs),其中关键基因通过RT-qPCR得到验证.

主要成果:

  • ETM降低了化能力,增加了形,并降低了生长速度.
  • 接受ETM治疗的小在热应激下出现了延迟喘气和较低的气温度,表明热耐受性得到改善.
  • 组织病理学揭示了神经元发育受损,而转录学显示了下丘脑神经发育,平衡和应激反应途径的改变,包括HSP70,GPX1,IL-6,apoptotic,DCX和AGRP基因表达的变化.

结论:

  • 电子培养可以提高的耐热性,但会损害化性能和大脑发育.
  • 观察到对下丘脑应激反应和神经发育基因网络的广泛干扰.
  • 结果为ETM提供了机械洞察力,并为改善家禽耐热性提供了参考.