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相关概念视频

Classifying Matter by Composition03:35

Classifying Matter by Composition

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Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures. 
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated. 
A mixture is composed of two or...
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Composition of Polyprotic Acid Solutions as a Function of pH01:19

Composition of Polyprotic Acid Solutions as a Function of pH

862
Polyprotic acids of the type H2M constitute two ionizable protons. As a result, on titration with a base, they exhibit two equivalence points in the titration curve. During titration, the species H2M, HM−, and M2− will be present in the solution at different points. The fractions of H2M, HM−, and M2− present at the various instances of the titration are denoted by α0, α1, and α2, respectively.
A graph with the alpha values is plotted against the volume of...
862
Energy Basics02:27

Energy Basics

47.5K
Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
47.5K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

100.9K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
100.9K
Basicity of Aliphatic Amines01:21

Basicity of Aliphatic Amines

6.9K
Amines can behave as Brønsted–Lowry bases by accepting a proton from the acid to form corresponding conjugate acids. Due to a lone pair of nonbonding electrons, aliphatic amines can also act as Lewis bases by forming a covalent bond with an electrophile.
To measure the basicity of amines, two conventions are generally used. The first defines Kb as the basicity constant for the deprotonation reaction of water by the amine, as presented in Figure 1. Conventionally, lower Kb indicates higher...
6.9K
Basic Operations on Signals01:22

Basic Operations on Signals

1.1K
Basic signal operations include time reversal, time scaling, time shifting, and amplitude transformations. These operations are fundamental in signal processing and analysis.
Time Reversal mirrors a continuous-time signal about the vertical axis at t=0. This is achieved by substituting t with −t. For example, if a signal x(t) is considered, the time-reversed signal is x(−t). This operation can be graphically represented, showing the mirrored signal.
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相关实验视频

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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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肠道微生物组的组成和功能:从基本的Omics到精准医学.

Yan Ma1, Lamei Wang1, Haitao Hu1

  • 1College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.

Genes
|January 28, 2026
PubMed
概括

肠道微生物群影响宿主健康,调节新陈代谢和免疫力. 进步将微生物组和宿主基因组学整合到精准医学中,使得针对癌症和神经退行性疾病等疾病的向治疗成为可能.

关键词:
健康和疾病健康和疾病.主体微生物的相互作用.人类微生物组的人类微生物组转基因组学是指转基因组学.多学科方法的多学科方法.

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科学领域:

  • 微生物组研究 微生物组研究
  • 基因组学就是基因组学.
  • 翻译医学是一种翻译医学.

背景情况:

  • 肠道微生物群,包括微生物群落及其产物,关键调节宿主代谢,免疫力和神经内分泌功能.
  • 了解微生物组与宿主相互作用是非常重要的,因为微生物组对健康的系统影响.
  • 最近的进展凸显了将微生物组数据与宿主基因组学整合的必要性.

研究的目的:

  • 提供对微生物组与宿主相互作用近期进展的系统概述.
  • 将微生物组的组成,功能和遗传学与宿主基因组学相结合.
  • 探索从基础研究到临床应用的技术管道.

主要方法:

  • 技术管道的审查,包括体外和体外模型.
  • 技术包括单个细菌的CRISPR编辑,有机微生物组共同培养和人性化的动物模型.
  • 应用多组学,机器学习和因果推理来实现个性化的益生菌设计.

主要成果:

  • 微生物组和宿主基因组学的整合提供了对它们相互作用的全面了解.
  • 一个技术管道有助于将微生物组研究转化为临床战略.
  • 基于微生物组关联的精确干预策略的开发.

结论:

  • 跨学科研究是将微生物群洞察力转化为有针对性的临床应用的关键.
  • 精确的微生物干预对治疗癌症,代谢和神经退行性疾病具有前景.
  • 这种方法构成了新一代精准医学的基础.