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Updated: Jan 29, 2026

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一种多基因酶抑制剂AX-0085阻断FGFR1激活,以克服非小细胞肺癌中奥西默提尼布抗性

Byung-Ho Rhie1,2, Janardhan Keshav Karapurkar3, Hyun-Yi Kim4

  • 1Institute of Medical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

Biomedicines
|January 28, 2026
PubMed
概括

作为AXL和FGFR1的双重抑制剂,AX-0085通过阻断关键信号通路,有效地克服了非小细胞肺癌 (NSCLC) 中对奥西默提尼布的耐药性. 这为耐药瘤患者提供了一个有前途的新疗法策略.

关键词:
AX-008585 这是一本书.一个AXL一个AXL一个FGFR1.在NSCLCLC中,我们可以看到.奥西默蒂尼布的耐药性是异常的

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