非热大气等离子调节小鼠部伤口愈合:一种形态测量,基因病理学和免疫基因化学分析
Basak Kusakci Seker1, Hakan Ozdemir2, Suna Karadeniz Saygili3
1Dentarma Private Oral and Dental Health Clinic, 07000 Antalya, Türkiye.
Biomedicines
|January 28, 2026
概括
非热大气等离子体 (NTAP) 通过促进细胞增殖和组织修复,显著增强口腔粘膜的愈合. 这项研究表明,NTAP加速了伤口关闭,并改善了 palatal 伤口中的血管化.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 在口腔外科手术.
背景情况:
- 非热大气等离子体 (NTAP) 通过调节细胞信号传递,显示出组织再生的潜力.
- 口腔粘膜愈合机制和受NTAP影响的分子通路需要进一步研究.
研究的目的:
- 研究NTAP对大鼠口腔伤口愈合的组织学和免疫组织化学效应.
- 评估关键生物标志物 (VEGF-A,TGF-β,FGF-2,CD34,α-SMA,Ki67) 在NTAP治疗的伤口愈合期间的血管生成,增殖和细胞外矩阵重塑.
主要方法:
- 60只老鼠接受了口腔创伤,并被分为盐水控制组 (SCG),素酸盐组 (CHG) 和NTAP治疗组 (NTAPG).
- 在术后7日,14日和21日进行了组织学和免疫组织化学分析,以评估血管化,炎症,原沉积,上皮化和生物标志物表达.
主要成果:
- NTAP治疗显著增加了TGF-β水平,α-SMA阳性细胞,FGF-2,VEGF-A和CD34的表达,表明增强的增殖和血管生成.
- 与对照组相比,NTAP减少了炎症细胞的透,并导致纤维细胞增殖,原沉积,血管化和重新上皮化改善.
- 组织学评估显示,NTAP组的伤口愈合加速.
结论:
- 通过增强的增殖活动和生长因子表达,NTAP显著促进部伤口愈合.
- NTAP加速组织修复,表明其作为口腔粘膜伤口愈合的有效治疗药物的潜力.
- 这项研究强调了NTAP在改善口腔粘膜的关键愈合参数方面的有效性.
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