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结肠直肠癌中的循环时钟基因:从分子机制到时间治疗应用

Haoran Wang^1,2, Jieru Zhou¹, Suya Pang¹

¹Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

|January 28, 2026

概括

循环时钟基因通过影响细胞周期和新陈代谢来调节结直肠癌 (CRC) 的进展. 了解这些时钟基因为CRC提供了新的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
时间生物学时间生物学

背景情况:

结肠直肠癌 (CRC) 的发病因子尚未完全理解,这阻碍了有效的治疗开发.
循环时钟基因,包括BMAL1,CLOCK,PER和CRY,都与CRC的启动和进展有关.
核心时钟基因调节关键的癌症特征,如细胞周期,上皮细胞-介质细胞转换 (EMT),新陈代谢和瘤微环境.

研究的目的:

系统地审查CRC中核心时钟基因的表达模式和机械作用.
通过信号通路阐明钟表基因参与CRC进展的分子基础.
讨论CRC中昼夜干扰对诊断,预后和治疗反应的影响.

主要方法:

关于时钟基因和结直肠癌的研究的系统文献综述.
对将时钟基因与CRC特征和信号通路联系起来的分子机制的分析 (例如,Wnt/β-catenin,c-Myc/p21).
评估昼夜干扰与CRC特征之间的关联,包括诊断标志物,预后和化学敏感性.

主要成果:

核心昼夜钟基因在调节CRC瘤发生方面发挥重要作用.
时钟基因影响关键的细胞过程,如细胞周期控制,EMT,代谢重编程和瘤微环境.
循环节障碍与改变的CRC诊断,预后和患者对化疗的反应有关.

结论:

核心时钟基因代表了新型CRC疗法的有希望的目标.
针对昼夜节律的慢性疗法策略对CRC管理具有翻译潜力.
需要进一步的研究来解决知识差距,并开发基于昼夜钟机制的CRC有针对性的干预措施.

关键词:

慢性治疗是一种慢性疗法.昼夜时钟是生物周期的时间表.昼夜基因是指昼夜基因的基因.结肠直肠癌是什么意思

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