在成年患有支气管喘患者的肠道微生物组成的性别特异性差异
Chihiro Hirano1, Yutaka Kozu2, Yusuke Jinno2
1Symbiosis Solutions Inc., Tokyo 101-0064, Japan.
Biomedicines
|January 28, 2026
概括
肠道微生物群失调与日本成年人的成年支气管喘 (BA) 有关,两性之间观察到不同的模式. 这项研究强调了需要考虑BA研究的肠道细菌的性别特异性差异.
科学领域:
- 微生物组研究的研究.
- 肺部病理学 肺部病理学
- 人类遗传学 人类遗传学
背景情况:
- 肠道微生物群失调与儿童喘有关.
- 它在成人支气管喘 (BA) 中的作用,特别是在日本人群中,尚不清楚.
- 肠道微生物群和BA的基于性别的差异需要研究.
研究的目的:
- 在日本队列中调查肠道微生物群组成和成人BA之间的关联.
- 探索这种关联中的性别特异性差异.
主要方法:
- 16S rRNA基因测序来自108名患有BA的日本成年人和210名健康对照人的便样本.
- 按性别分层分析.
- 评估β多样性和属级分类学比较.
主要成果:
- 在BA患者和对照人群之间肠道微生物群β-多样性的显著差异.
- 在两性BA患者中*Streptococcus*和*Blautia*的丰富.
- 性别特定的细菌种群变化,包括男性的*Veillonella*和女性的*Flavonifractor*/*Eggerthella*,以及BA患者短链脂肪酸 (SCFA) 生产细菌的减少.
结论:
- 肠道微生物群失调症在日本成年人中存在.
- 这种失生症涉及与呼吸道疾病相关的细菌的丰富以及SCFA产生细菌的枯竭.
- 肠道微生物群组成的性别特异性是BA研究和潜在治疗策略的重要考虑因素.
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