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老年大脑中的微血管衰竭:氧化应激,炎症和内皮衰退的融合途径

Jordana Mariane Neyra Chauca¹, Maclovia Vázquez VanDyck¹, Armando Espinoza Santana²

¹Facultad de Medicina, Universidad Autónoma de Guadalajara, Guadalajara 45129, Mexico.

|January 28, 2026

概括

衰老通过氧化应激,炎症和内皮衰老损害了微循环,影响了外围动脉疾病和大脑健康. 这种系统性问题影响了血脑屏障的完整性和神经血管功能.

科学领域:

血管生物学血管生物学
衰老研究研究衰老研究
神经科学是一个神经科学.

背景情况:

老化逐渐影响微循环系统,影响外周和脑血管的内皮稳定性.
氧化失衡,炎症和内皮疲劳会破坏微血管网络的稳定,将外围动脉疾病 (PAD) 与大脑功能障碍联系起来.
恶化的氧化还原稳定会损害内皮屏障功能和通信,促进神经血管损伤.

研究的目的:

审查氧化应激,炎症,内皮衰老和血脑屏障 (BBB) 破坏之间的相互作用的机械证据.
为了比较外围动脉疾病和大脑微循环病理,以确定共享的分子驱动因素.
了解衰老中内皮质恶化的全身机制.

主要方法:

叙述性审查整合实验,临床和翻译研究.
对外围动脉疾病和老化大脑循环的比较分析.
专注于将氧化应激,炎症,衰老和BBB完整性联系在一起的分子机制.

主要成果:

氧化应激会破坏线粒体功能,紧张的结节和血管生成.
炎症通过细胞因子激活和白细胞粘附来放大内皮功能障碍.
内皮衰老导致氧化的减少,毛细血管稀疏和屏障完整性的损害,这在PAD和老化大脑中很常见.

结论:

老化大脑中的微血管衰竭是系统性内皮质恶化的延伸.
共同的分子通路连接了外周和大脑的微循环功能障碍,表明了统一的衰老表型.
向内皮弹性和BBB完整性为老年人群提供治疗策略.

关键词:

血脑屏障血脑屏障血脑屏障血脑屏障内皮质功能障碍在内皮质功能障碍这是一种炎症炎症炎症炎症.微循环是一种微循环.微血栓形成的微血栓形成神经血管单位神经血管单位氧化应激是一种氧化应激.周围动脉疾病是什么血管衰老血管衰老

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