周围血液细胞和临床概况作为缓解护理患者疼痛检测的生物标志物
Hugo Ribeiro1,2,3,4, Raquel Alves2,3,5, Joana Jorge2,3,5
1Community Palliative Care Support Team Gaia, Health Local Unit Gaia and Espinho, 4434-502 Vila Nova de Gaia, Portugal.
Biomedicines
|January 28, 2026
概括
这项研究探讨了临床因素和血液生物标志物,以确定息治疗患者的疼痛,特别是痴呆症患者. 研究结果表明,年龄,功能和特定的血细胞标记物可以预测疼痛.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 生物标志物 生物标志物
- 疼痛管理 疼痛管理
背景情况:
- 息护理患者是复杂的,经常经历难以自我报告的疼痛.
- 在息治疗机构内,痴呆症患者的疼痛诊断往往不足.
研究的目的:
- 调查临床参数和外围血液生物标志物,以识别和描述息护理患者的疼痛.
- 在一个包括痴呆症患者在内的队列中探索潜在的疼痛预测因素.
主要方法:
- 对53名患有非瘤性疾病的患者进行横截面研究.
- 使用流细胞计和后勤回归分析医疗/护理记录,临床参数 (年龄,功能,营养) 和外周血液生物标志物 (单细胞,血小板).
主要成果:
- 慢性疼痛与晚年相关,减少淋巴膜过率 (GFR) 和营养不良.
- 潜在的疼痛预测因素包括淋巴细胞和单细胞百分比,CD206/CD163的单细胞表达,CD163/CD206的比例,以及血小板CD59的表达.
- 一个模型表明,样本中的所有65岁以上的患者都报告了疼痛.
结论:
- 初步证据将息治疗中的慢性疼痛与衰老,营养不良和功能障碍联系起来.
- 新的外周血液生物标志物在复杂的患者群体中显示出对疼痛评估的前景.
- 临床和分子生物标志物可以增强疼痛检测和管理,以提供个性化的息护理.
关键词:
年长的年长的老年人生物标志物 生物标志物痴呆症 痴呆症是一种痴呆症.营养不良 营养不良 营养不良单细胞 (Monocytes) 是一种单细胞.疼痛评估疼痛的评估.血小板 血小板 是功能不良 功能不良更多相关视频
相关概念视频
Patient-centered Care
3.0K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
Peripheral Artery Disease III: Interprofessional Care
308
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
308
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
840
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
840
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
414
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
414
Blood Studies for Cardiovascular System III: Serum Lipid Profile
610
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
610
Pain
1.4K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.4K


