对于晚期胰腺癌的当前系统性治疗选择 - - 一篇综述文章
Małgorzata Domagała-Haduch1, Anna Długaszek1, Anita Gorzelak-Magiera1
1Department of Oncology and Radiotherapy, Medical University of Silesia, 40-514 Katowice, Poland.
Biomedicines
|January 28, 2026
概括
胰腺癌的生存率很差,晚期诊断限制了治疗选择. 虽然像FOLFIRINOX这样的化疗显示出希望,但先进的胰腺癌研究正在探索向疗法和免疫疗法,以获得更好的结果.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 胰腺腺癌是一种具有攻击性的恶性瘤,发病率不断增加,预后不佳.
- 由于无症状的早期阶段,晚期诊断很常见,将治愈治疗选择限制在10%至20%的患者.
- 晚期疾病往往不能进行手术,大约一半的患者被诊断出转移性阶段.
研究的目的:
- 审查目前针对晚期胰腺癌的治疗策略.
- 突出系统治疗的作用,包括化疗,向药物和免疫治疗.
- 讨论基于国家综合癌症网络指南和PubMed文献的发现.
主要方法:
- 基于国家综合癌症网络指南的文献综述.
- 分析来自PubMed数据库的出版物.
主要成果:
- 在转移性胰腺癌中,FOLFIRINOX 化疗提供了较好的中位生存期 (11 个月),相比于 gemcitabine 和 nab-paclitaxel (8.5 个月).
- 在晚期胰腺癌中,olaparib维持疗法延长了无进展的存活率,但不是总体存活率.
- 免疫疗法和向治疗目前仅限于特定的患者亚组,这表明需要进一步研究.
结论:
- 系统治疗仍然是晚期胰腺癌的基石.
- 向药物和免疫疗法显示出潜力,但需要进一步研究以获得更广泛的应用.
- 持续的研究对于开发胰腺腺癌的新有效治疗方法至关重要.
相关概念视频
Overview of Advanced Functional Groups
29.7K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.7K
Overview of Systemic Arteries
1.8K
The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the...
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the...
1.8K
Overview of Systemic Veins
1.2K
Systemic veins are crucial blood vessels that return deoxygenated blood from various body tissues back to the heart. There are three systemic veins that return deoxygenated blood to the heart, they are as follows.
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the...
The coronary sinus, the heart's principal vein, resides in the coronary sulcus on the heart's posterior aspect. This broad venous channel receives nearly all venous blood from the myocardium, the heart muscle. It is fed by three primary veins: the great cardiac vein, the...
1.2K
Controlled-Current Coulometry: Overview
687
Controlled current coulometry, also known as amperostatic coulometry, is a technique used in electrochemical analysis to measure the quantity of a substance through the controlled passage of current. It involves the application of a constant current to an electrochemical cell containing the analyte of interest. As the current flows through the cell, the analyte undergoes a redox reaction at the electrode surface, resulting in a charge transfer. By monitoring the time required for a certain...
687
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Overview of Systemic and Pulmonary Circulation
10.7K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
The oxygenated blood is sent...
10.7K


