在过敏性鼻炎中评估氧化应激和抗氧化剂状态
Ahmet Burak Gürpınar1, Selen Karaoğlanoğlu2
1Department of Medical Biochemistry, Faculty of Medicine, Tokat Gaziosmanpaşa University, 60030 Tokat, Türkiye.
Biomedicines
|January 28, 2026
概括
过敏性鼻炎患者表现出受损的硫化类固态稳定和增加的氧化应激. 这些标记物,包括总醇和本地醇,可能有助于诊断过敏性鼻炎.
科学领域:
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 过敏性鼻炎 (AR) 是一种慢性IgE介导的炎症性疾病.
- 氧化应激 (OS) 在AR中起着重要作用.
- 二硫化物平衡 (TDH) 是一个关键的生化平衡.
研究的目的:
- 调查AR患者与健康对照中的动态TDH和OS标志物.
- 评估OS标记和实验室参数之间的相关性.
- 评估AR中OS标志物的诊断性能.
主要方法:
- 招募了31名AR患者和31名健康对照.
- 测量了血液学和生物化学参数.
- 评估的OS标志物:总醇 (TT),原生醇 (NT),二硫化物,总抗氧化状态 (TAS),总氧化状态 (TOS) 和氧化应激指数 (OSI).
- 进行了相关性和ROC分析.
主要成果:
- 复发性肺炎患者的TT和NT水平较低,二硫化物,二硫化物/NT,二硫化物/TT比率,TOS和OSI较高.
- 在AR患者中,TAS水平略低一些.
- TT和NT与乙素,单细胞,血小板,AST和肌素相关.
- ROC分析显示了TT,NT和二硫化物标记物的诊断潜力.
结论:
- AR与破坏的TDH和升高的OS相关.
- 这些OS标记可以作为AR中氧化失衡的敏感指标.
- 确定了AR管理的潜在诊断和治疗见解.
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